对于纳米制剂的PBPK模型，PK-Sim可以被用来建立和模拟该制剂在体内的吸收、分布、代谢和排泄过程。
01、健康对照个体 搭建肝肾损伤的PBPK模型,首先都需要搭建一个对照人群,所以首先在PK Sim的building blocks中添加一个“individual”,命名为“control”,人群特征可以按照目标模拟的人群进行设置。点击next直到“expression”部分,然后添加你所要建模药物的酶、转运体或者特殊蛋白的参数,这里可以利用PK Sim的标记功能,即Phe...
这要求我们利用PK-Sim构建一个生理药代动力学(PBPK)模型,作为对照。假设我们要模拟一位35岁、体重70公斤的健康男性对某药物的代谢情况,需在PK-Sim的“building blocks”中添加一个名为“control”的个体,并输入其年龄、性别、体重等基础信息,同时根据药物的特性设定相应的酶、转运体参数。这一过程如同为药物代谢的...
PBPK and QSP model implementation and utilization in R (Part 1) 1438 -- 4:57 App 一个人复现 ChatGPT,能做到什么程度? 4.9万 32 0:50 App 千万别乱吃叶黄素!! 18.7万 22 1:31 App 灭绝人性的实验。恐怖的人兽杂交 2.9万 28 1:22 App 计算:5⁵×8⁸=? 全班算得脸都红了! 412 -- 1...
development of a combined immediate release鈥揷ontrolled release formulation has been described.Conclusions Future perspectives of the use of PBPK modelling have been discussed, with a special focus on the integration of in-vitro dissolution data into PBPK models for oral and non-oral administration ...
PK-Sim® is a novel whole-body PBPK in silico model that can be used throughout all stages of the drug R&D process. It was developed, tested and evaluated in real-life projects within the pharmaceutical industry. It is expected that additional modules will be validated and become available...
PBPKmodel qualificationadult-to-children PK extrapolationPediatric physiologically based pharmacokinetic (PBPK) models facilitate the estimation of pharmacokinetic (PK) parameters in children under specific exposure conditions. In human health risk assessment, PBPK modeling has been used to determine a ...
运用PK-sim预测异甘草酸镁在人体中暴露浓度的方法.pdf,本发明公开了运用PK‑sim预测异甘草酸镁在人体中暴露浓度的方法,步骤为:(1)确立PBPK模型结构和质量平衡方程;(2)收集文献中临床异甘草酸镁的血药浓度;(3)用PK‑sim建立PBPK模型并对所建立的模型参数进行拟合求解
However, there is a lack of comparative analyses of both platforms and their potential impact on PBPK models. This study aims to evaluate the influence of different platforms on PBPK workflow, parameters selection, and output results, which is exemplified via a case study for meloxicam in ...
The objectives of this study were to extend a whole-body pregnancy PBPK model by multiple compartments representing fetal organs, and to predict the PK ... XI Liu,DJ Green,van den Anker, JohnAhmadzia, Homa K.Burckart, Gilbert J.Dallmann, Andre - 《Clinical Pharmacokinetics》 被引量: 0发...