5. Pietrantonio et al. Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial. JAMA Oncol. 2019 ...
5. Pietrantonio et al. Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial. JAMA Oncol. 2019 Sep 1;5(9):1268-1275. 6. Modest DP, et al. Panitumumab Plus Fluorour...
[32] Huang Z, Fish W P. Development of simple isocratic HPLC methods for siRNA quantitation in lipid-based nanoparticles[J]. Journal of Pharmaceutical and Biomedical Analysis, 2019, 172: 253-258. [33] Kato M. Overview of the state-of-the-art liposomal drug analysis using high-performance ...
[32] Huang Z, Fish W P. Development of simple isocratic HPLC methods for siRNA quantitation in lipid-based nanoparticles[J]. Journal of Pharmaceutical and Biomedical Analysis, 2019, 172: 253-258. [33] Kato M. Overview of the state-of-the-art liposomal drug analysis using high-performance l...
Various PK methodologies can be employed in clinical trials, such as non-compartmental analysis, population pharmacokinetics, andphysiologically based pharmacokinetic modeling.在临床试验中可以采用各种PK方法学,如非常规分析、种群药代动力学和生理药代动力学建模。 Non-compartmental analysis is commonly used to ...
表3 聚合胶束相关药物临床试验(clinicaltrials.gov)[15] 胶束在口服药物中的应用 据报道,塞来昔布口服给药系统使用的是由Soluplus®(聚乙烯己内酰胺-聚乙酸乙烯酯-聚乙二醇接枝共聚物)和Kolliphor®HS-15(聚乙二醇(15)-羟基硬脂酸酯)聚合物形成的胶束。研究发现,与上市配方相比,胶束可提高药物在大鼠体内的生物利用...
[6]Yu Z, et al. Clinical outcomes of prolonged infusion (extended infusion or continuous infusion) versus intermittent bolus of meropenem in severe infection: A meta-analysis. PLoS One. 2018 Jul 30;13(7):e0201667. [7]Ambrose PG, Bhavnani SM, Ellis-Grosse EJ, Drusano GL. Pharmacokineti...
phase 1 clinical trialsclinical pharmacologysafetypharmacokineticsorgan failurepharmacodynamicsPharmacokinetics (PK) is affected by aging, organ functions, concomitant drugs, etc.; hence, determining the dose and target blood concentration from PK/PD analysis based on pharmacodynamics (PD) that uses ...
Non Compartmental analysis The first main feature of PKanalix is the calculation of the parameters in the Non Compartmental Analysis framework. This task consists in defining rules for the calculation of the Lambda_z (slope of the terminal elimination phase) to be able to compute the NCA paramet...
• PK analysis using WinNonlin In order to provide a significant enhancement in speed and efficiency it becomes highly beneficial in Creative Animodel to conduct both the in vivo PK quantification and identification of the major metabolites on a single instrument platform. Creative Animodel provides...