Methods: Patients with normal or reduced kidney function underwent a non-contrast computed tomography scan of the entire aorta with subsequent blinded standard calcification scoring of the aortic wall ad modum Agatston. Blood samples were analyzed for plasma concentrations of dp-ucMGP and PIVKA-II. ...
Using multiple reaction monitoring-mass spectrometry (MRM-MS), good linearity (R (2)=0.9988) was obtained for PIVKA-II over a range of 3 orders. We achieved a limit of detection (LOD) of 0.45 nM (31.72 ng/mL), a limit of quantification (LOQ) of 0.93 nM (65.31 ng/mL), a lower ...
Serum PIVKA-II levels exceeded the reference value (<40 mAU/mL) in 13 of 20 patients (65%). Increased serum ucOC levels were also found in 9 patients (45%). We compared the clinical parameters between patients with SMID who had normal PIVKA-II levels (n = 7) and those with ...