研究还发现,Pitavastatin对血脂和炎症生物标志物的水平也具有显著影响。与安慰剂组相比,Pitavastatin组在24个月时低密度脂蛋白胆固醇平均降低-28.5 mg/dL(95%CI:-31.9～-25.1),而安慰剂组仅降低0.8 mg/dL,(95%CI:-3.8～2.2),两组间差异...
商品名 Pitavastatina Biofarmoz 活性成分 pitavastatin null 2 mg 通用名称 pitavastatin 中文名称 匹伐他汀 剂型 Film-coated tablet MR编号 PT/H/2682/002 申请类型1 Prescription Only 申请类型2 Initial Application 申请类型3 Generic Art 10.1 and 10.2 Dir 2001/83/EC ...
In each panel, subjects were randomized to receive a single oral dose of rosuvastatin (5 mg) or pitavastatin (1 mg) administered alone, concomitantly with rifampicin (600 mg) PO or IV. The in vitro transporter studies were performed using hepatocytes and recombinant expression systems....
In short-term, phase III or IV studies in this patient population, pitavastatin 1–4 mg once daily was generally no less effective than presumed equipotent dosages of atorvastatin and simvastatin (including in patients with type 2 diabetes or ≥2 cardiovascular risk factors) and was ...
Incidence of NOD was similar between the pitavastatin 1 mg and 4 mg groups [12 of 289 patients (4.2%) and 8 of 289 patients (2.8%), respectively; p = 0.36]. In a prespecified analysis, there were no significant differences in NOD events according to sex, age, diagnosis, body ...
Eligible patients were randomized into 2 groups in a 1:1 ratio. Patients received pitavastatin 2 mg once daily or simvastatin 20 mg once daily for 8weeks. The medication was administered initially for 4 weeks, and an additional 4 weeks of study medication was prescribed at week 4. The final...
An analysis was performed on the relationship between the afore-mentioned SNPs and dose-normalized (based on 1 mg) area under the plasma concentration-time curve extrapolated to infinity [AUC((0.infinity.))] and peak plasma concentration (C-max) values of the acid and lactone forms of ...
Objective: We have investigated the effect of pitavastatin, a newly developed statin, on atherosclerosis in rabbits. Methods and results: Oophorectomized female NZW rabbits were fed 0.3% cholesterol chow for 12 weeks with or without pitavastatin (0.1 mg/kg per day) (Gp.NK and HCD). The ...
Results Administration of 2mg single-dose pitavastatin to patients with Child-Pugh grade A and grade B cirrhosis resulted in a 1.19- and 2.47-fold increase in C max and 1.27- and 3.64-fold increase in AUCt, respectively, when compared with normal subjects. The geomean C max of pitavastatin...
Methods Twelve Chinese healthy male volunteers took 4 mg pitavastatin orally with 150 ml water or with a single dose of 600 mg rifampin on separate occasions and the plasma concentrations of pitavastatin were measured over 48 h by HPLC-MS/MS. Results A single dose of rifampin ...