Piperazine shows high activity againstA. suumandOesophagostomumspp. in pigs at a dose of 250-300mg/kg given in feed or water. The drug is equally effective in eliminating the common ascarids of cats and dogs at a dose of 100-250mg/kg base administered orally as a salt[56,58]. ...
For cats and dogs, the usual dose is 200mg per kg of body weight, given at 9 months old. Repeat the dose every 3 months. It should be noted that the dose may be different according to regional regulations. Refer to a veterinary doctor or pharmacist for guidelines on dosage. Side Effect...
A therapeutic dose is typically sufficient considerably to reduce the undesired cell population in the target tissue while the viability of the patient is maintained. The treatment is generally continued until a considerable reduction has occurred, for example an at least about 50% reduction in the ...
Nonlinear regression graphs were plotted in GraphPad Software GraphPad Prism 6.04 [35] to yield sigmoidal dose−response curves and half-maximal effective concentration (EC50) values were determined. 4.49. Cytotoxicity of compounds against HepG2 cells HepG2 (Hepatocyte) cells were seeded in 96-...
values ranging from 0.1 to 0.5 µg/mL in HeLa, HepG2, and MCF7 human cancer cell lines were determined using the MTT assay for (+)-gliocladicillin A (5) and (+)-gliocladicillin B (6), and tumor cell apoptosis was shown to be induced in a time- and dose-dependent manner....
Compound DGG200064 did not cause apoptosis, but it induced G/2M arrest in a dose- dependent manner in HCT116 cells (Figure 2a). Additionally, DGG200064 was tested for induced G2/M arrest in the other types of colon cancer cells in concentrations of 50 nM for 6 h (Figure 2b). 2.3. ...