Full size image PXN-AS1 acts as a sponge for miR-3064 to repress its expression in PC cells Using the online software starBase v2.0 [17], we found that lncRNA PXN-AS1 could form a complementary base pairing with miR-3064 (Fig. 6a). To investigate the role of PXN-AS1 in PC, we fi...
It is unlikely that many individuals with SH3 variants in our cohort also have full-blown PAPA syndrome, as PAPA syndrome is an orphan disease with few patients identified worldwide. Also of interest, there is a report of an individual with PASH who had a LoF variant in NCSTN.63 These ...
4.2. RNA Interference For the RNAi of ppk-1, we used the full coding sequence of 1836 bp (F55A12.3) from C. elegans cDNA. The primers used were as follows: forward 5 -CCCGGGATGGCTTCTCGGTCCAC-3 and reverse 5 -CCATGGTCAAGCGACAGGTGTGT-3 . The sequence was cloned to a L4440 feeding...
In summary, our study suggested that WDR73 can interact with PIP4K2C to form a complex with a function in FA assembly and regulates PIP4K2C protein stability through the autophagy–lysosomal pathway. This study would provide a new perspective on the molecular mechanism of WDR73 in primary alb...