Mechanism of actionThe mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium sensitisation of troponin C and promotes vasodilatation by inhibiting PDEIII. ...
Pimobendan exerts a stimulatory myocardial effect by a dual mechanism of action consisting of an increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (Type III). Pimobendan exhibits vasodilating activity by inhibiting phosphodiesterase III activity. The chemical ...
Overall, pimobendan enhances systolic function by improving the efficiency of contraction, limiting the potential arrhythmogenicside effectsof other positiveinotropeswhose sole mechanism of action is to increase myocardial intracellular calcium. Calcium sensitizers such as pimobendan may thus represent the ...
While pimobendan prolonged action potential durationin vitro, it shortened ventricular refractorinessin vivo, and lacked antiarrhythmic activity in a canine postmyocardial infarction model of sudden cardiac death. Instead, pimobendan (0.3 mg/kg intravenously) increased the incidence of ischaemic ventricul...
Formulations containing pimobendan have been used in the treatment of heart failure in dogs. Biochem/physiol Actions Pimobendan is an inotropic agent with a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilation ...