See Table 3 for cardiac pathology results. The cardiac pathology/histopathology noted in the 3X and 5X dose groups is typical of positive inotropic and vasodilator drug toxicity in normal dog hearts, and is associated with exaggerated hemodynamic responses to these drugs. None of the dogs developed...
The same VETMEDIN treatment you’ve prescribed for your CHF patients for years is also available in a liquid oral solution. Newly available VETMEDIN Solution makes administration easy for dogs who prefer liquid medication and delivers just the right dose they need. ...
Our main objective was to produce printlets from natural polymers to tailor PBD dosages specifically for the needs of small to medium-sized dogs with MMVM. Printlets of various shapes and sizes were produced by semisolid extrusion, as controlled drug release systems, to tailor the drug dose....
Background: Pimobendan is an important therapy for dogs with myxomatous mitral valve disease (MMVD). The pharmacokinetics are reported in healthy dogs but not in dogs with heart disease. Hypothesis/Objectives: To determine if dog characteristics such as age, breed, body condition s...
Pimobendan is well absorbed following oral administration, with a bioavailability of ≈ 70% in healthy young volunteers. The pharmacokinetic properties of the drug are linear over intravenous and oral dose ranges of 2.5 to 5mg and 1.25 to 10mg, respectively. Mean peak plasma concentrations of pi...
Pimobendan is a drug with both inotropic and vasodilatory properties and is widely used for the treatment of heart failure in dogs. The best evidence regar... A Boswood - 《Veterinary Clinics of North America Small Animal Practice》 被引量: 26发表: 2010年 ...
and peak serum concentration is nine times higher in cats given the same mg/kg dosage as dogs.32Despite such findings, the dosage that is approved for dogs is routinely given to cats.29–31,fThe risk–benefit ratio of such an approach is unknown, either in the short term or long term....
Calculated based on pimobendan. Oral dose for dogs: 0.25 mg/kg body weight twice daily. ADVERSE REACTIONS: 1. A slight positively chronotropic effect (rise in heart rate) and vomiting may occur in a very small number of affected dogs. However, these effects are dose-dependen...
Findings were recorded in these dogs for an additional 4 months or longer. During this time, the incidence of sudden death was less in the pimobendan group compared with the digoxin group. It isconcluded that pimobendan at a daily dose of 0.5 mg/kg can be recommended for treating ...
pharmacokineticstudy in Hispaniolan Amazon parrots(Amazona ventralis)demonstrating that a single oral dose of 10 mg/kg is required to achieve a peak plasma concentration of 8.26 ng/mL, comparable with levels considered therapeutic in dogs and humans.306An oral suspension formulated from commercially ...