The drug's dosage for dogs range from 0.2 to 0.6 milligram/kilogram daily and administered twice a day with 12 hours interval. It states that the effectiveness of Pimobendan in cats has not been indicated.ThomasonDepartmentJustinDepartment
Only for use in dogs with clinical evidence of heart failure. At 3 and 5 times the recommended dosage, administered over a 6-month period of time, pimobendan caused an exaggerated hemodynamic response in the normal dog heart, which was associated with cardiac pathology (See Animal Safety). ...
For the heart, from the start, VETMEDIN chewable tablets are indicated for the treatment of congestive heart failure in dogs.
Pimobendan has shown limited effect on New York Heart Association (NYHA) functional status when the latter has been employed as a therapeutic end-point in heart failure. In patients receiving diuretics for moderate congestive heart failure, adjunctive therapy with pimobendan 5mg twice daily (titra...
Pimobendan (PBD), a veterinary drug only, is prescribed in specific cases of chronic heart disease in dogs and is available on the market in only a few different doses. Furthermore, the therapy itself is challenging due to the large size of the chewable tablets and the requirement for ...
and peak serum concentration is nine times higher in cats given the same mg/kg dosage as dogs.32Despite such findings, the dosage that is approved for dogs is routinely given to cats.29–31,fThe risk–benefit ratio of such an approach is unknown, either in the short term or long term....
of EP0439030 Pimobendan dosage forms for oral administration contain citric acid, ensuring constantly good absorption even with large pH variations in the gastrointestinal tract. PC Gruber,WC Roth,G Schepky 被引量: 26发表: 1993年 Comparison of hormonal and haemodynamic changes after long-term oral...
DOSAGE AND ADMINISTRATION: Calculated based on pimobendan. Oral dose for dogs: 0.25 mg/kg body weight twice daily. ADVERSE REACTIONS: 1. A slight positively chronotropic effect (rise in heart rate) and vomiting may occur in a very small number of affected dogs. However, these...
摘要: Pimobendan dosage forms for oral administration contain citric acid, ensuring constantly good absorption even with large pH variations in the gastrointestinal tract.收藏 引用 批量引用 报错 分享 全部来源 求助全文 掌桥科研 相似文献Oral pharmaceutical forms of pimobendan...
Dosage: • Dogs: 0.1 to 0.25 mg/kg PO every 12 hours; give 1 hour prior to food ingestion • Pimobendan Pimobendanderives itsinotropiceffect from a combination ofphosphodiesteraseIII inhibition and sensitization of myocardialcontractile proteinsto calcium [31]. ...