DOGSTHERAPY dogsPHARMACOKINETICSBackground: Pimobendan is an important therapy for dogs with myxomatous mitral valve disease (MMVD). The pharmacokinetics are reported in healthy dogs but not in dogs with heart disease. Hypothesis/Objectives: To determine if dog characteristics such as a...
Pimobendan has been studied for treating heart failure and cardiomyopathy, primarily for veterinary uses. Mechanism of action The mechanism of mild mitral regurgitation (MR) in dogs treated with Pimobendan is a dual mechanism of action, which enhances myocardial contractility by increasing calcium ...
pimobendan has been well tolerated in small groups of patients with chronic heart failure. Treatment withdrawal due to adverse events was not significantly more frequent with pimobendan 2.5 to 10 mg/day (9%) than with placebo (4%) over a 3-month treatment period. Headache...