Only for use in dogs with clinical evidence of heart failure. At 3 and 5 times the recommended dosage, administered over a 6-month period of time, pimobendan caused an exaggerated hemodynamic response in the normal dog heart, which was associated with cardiac pathology (See Animal Safety). ...
pimobendan has been well tolerated in small groups of patients with chronic heart failure. Treatment withdrawal due to adverse events was not significantly more frequent with pimobendan 2.5 to 10 mg/day (9%) than with placebo (4%) over a 3-month treatment period. Headache...
Pimobendan (PBD), a veterinary drug only, is prescribed in specific cases of chronic heart disease in dogs and is available on the market in only a few different doses. Furthermore, the therapy itself is challenging due to the large size of the chewable tablets and the requirement for ...
and peak serum concentration is nine times higher in cats given the same mg/kg dosage as dogs.32Despite such findings, the dosage that is approved for dogs is routinely given to cats.29–31,fThe risk–benefit ratio of such an approach is unknown, either in the short term or long term....
Effect of Pimobendan on Echocardiographic Values in Dogs with Asymptomatic Mitral Valve Disease Background: Pimobendan (PIMO) is a novel inodilator that has shown promising results in the treatment of advanced mitral valve disease (MVD), but little i... M Ouellet,MC Bélanger,R Difruscia,....
DOSAGE AND ADMINISTRATION: Calculated based on pimobendan. Oral dose for dogs: 0.25 mg/kg body weight twice daily. ADVERSE REACTIONS: 1. A slight positively chronotropic effect (rise in heart rate) and vomiting may occur in a very small number of affected dogs. However, these...
Pimobendan has been used in birds at the empirical dosage of 0.25 mg/kg. To determine the pharmacokinetic parameters, 3 pilot crossover studies with 2 birds, each receiving 1, 3 and 10 mg/kg PO, provided the basis for 2 trials with 6 birds, each receiving 10 mg/kg PO using 2...
Dosage: • Dogs: 0.1 to 0.25 mg/kg PO every 12 hours; give 1 hour prior to food ingestion • Pimobendan Pimobendanderives itsinotropiceffect from a combination ofphosphodiesteraseIII inhibition and sensitization of myocardialcontractile proteinsto calcium [31]. ...