S8005SMI-4aSMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases. Transl Gastroenterol Hepatol, 2024, 9:14 ...
Pim inhibitor TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). Quick View A12896 CX-6258 Pim Inhibitor CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor. ...
SGI-1776 (PIM抑制剂) 基本信息 中文名称SGI-1776 (PIM抑制剂) 中文同义词SGI-1776 (PIM抑制剂) 英文名称SGI-1776 (PIM inhibitor) 英文同义词 CAS号 分子式 分子量0 EINECS号 相关类别免疫与炎症;试剂;抑制剂激活剂等;Jak/Stat:IL-6 Signaling
2. Chen L, Mao W, Ren C, et al. Comprehensive Insights that Targeting PIM for Cancer Therapy: Prospects and Obstacles[J]. Journal of Medicinal Chemistry, 2024. 3. Liu C, Liu B, Xu C, et al. ETH-155008, a novel select...
别名:PIM1/2 Kinase Inhibitor VI 特别提示:包括Pim激酶抑制剂(SMI-16a)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!产品名称:Pim激酶抑制剂(SMI-16a)英文名称:SMI-16a产品货号:M02581产品规格:1mL(10mM)|5mg|10mg|25mg|50mgSMI-16a是选择性的Pim激酶抑制剂,对Pim1,Pim2和PC3...
SMI-16a是选择性的Pim激酶抑制剂,对Pim1,Pim2和PC3细胞的IC50值分别为0.15,0.02和48μM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:587852-28-6别名:PIM1/2 Kinase Inhibitor VI纯度:98.0%分子式:C13H13NO3S分子量:263.31结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个...
别名PIM inhibitor 1 CAS2088852-47-3 分子式C26H26F3N5O3.H3O4P 分子量611.51 储存条件2-8℃ 纯度≥98% 单位瓶 SMILESO=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=CN=C4C(CC[C@H]4O)=C3N5C[C@@H](N)[C@H](O)[C@@H](C)C5.OP(O)(O)=O ...
PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathwayB-ALLSMI-4aJAK2/STAT3ApoptosisObjectives: The serine/threonine PIM protein kinases are critical regulators of tumorigenesis in multiple cancers. However, whether PIMs are ...
PIM1 interaction inhibitorNSC756093. Using the inhibitor in IFN-γ–activated patient-derived tumor organoids increased organoid death and prevented organoid reformation. Thus, we found that PIM1 and 14-3-3σ together controlled the activity of GBP1 in human cells. Disrupting PIM1-driven control ...
PIM-1 Inhibitor 2 477845-12-8sc-204194 sc-204194A 10 mg 50 mg $132.00 $559.00 1 (0) 一种Pim-1激酶的特异性抑制剂,可降低其致癌潜力。 SMI-4a 327033-36-3sc-364140 5 mg $93.00 2 (0) 一种强效且具有选择性的Pim-1激酶抑制剂。它可阻断Pim-1活性,并诱导多种癌细胞系凋亡。