FimbriaeOptical tweezersUnfoldingUropathogenic Escherichia coliS pili are members of the chaperone-usher-pathway-assembled pili family that are predominantly associated with neonatal meningitis (S(II)) and believed to play a role in ascending urinary tract infections (S(I)). We used force-measuring ...
However, the mechanisms by which oral pathobionts thrive in the inflamed oral mucosa and subsequently re-adapt to the gut environment remain largely unclear. Given the difference in the microenvironment between the oral and gut mucosae, oral pathobionts likely utilize different strategies for colonizat...
tuberculosis by negative staining and transmission electron microscopy (TEM), we noted the presence of fibrillar structures resembling pili (also called fimbriae) when the bacteria were propagated under suitable laboratory growth conditions. Namely, cultures of various M. tuberculosis strains (avirulent H...
Adherence and colonization are acknowledged first steps in the pathogenesis ofH. influenzae. As such,H. influenzaeexpress multiple adhesins including hemagglutinating pili, fimbriae and non-fimbrial adhesins (Gilsdorf et al.,Pediatr Res39, 343-348, 1996; Gilsdorf.,Infect. Immun.,65, 2997-3002, ...
Intraperitoneal administration of the PapDG vaccine protects animals from infection and elicits a specific IgG antibody response in cynomolgus monkeys [118,122]. The Dr fimbriae represents another current vaccine target. Mice vaccinated with purified Dr fimbriae produce high titers of serum antibodies ...
Indeed, TEM analysis of flagellaless mutants carrying single large deletions in either the flp-1 or flp-2 clusters revealed the production of filaments, while these fimbriae structures were no longer observed in a flagellaless double flp-1flp-2 mutant. These results indicate that, under our ...