anti-tumor necrosis factorinterferon gamma release assaylatent tuberculosispsoriasisscreeningBackground Bazex–Dupré–Christol syndrome (BDCS) is an X-linked dominantly inherited disorder affecting hair follicle structures. Currently, hypotrichosis, follicular atrophoderma and basal cell carcinomas are ...
This is caused by the blockage of the sympathetic nerve impulses to the iris pigment cells (melanocytes) due to many different reasons, such as a tumor or injury. This suggests that stimulation of melanocytes by nerves may also be important for melanogenesis and that inhibition of sympathetic ...
Author(s): Hong Jiang 1 , Jacobo Wortsman 2 , Lois Matsuoka 3 , Jacqueline Granese 4 , J Andrew Carlson 5 , Martin Mihm 6 , Andrzej Slominski [[dagger]] 7 Keywords: atypical pigmented lesions; melanocyte transformation; melanocytic nevus; melanoma; molecular biology; tumor progression ...
hair follicle stem cellmelanin pigmentPigmented epithelioid melanocytoma (PEM) is a tumor encompassing epithelioid blue nevus of Carney complex (EBN of CNC) and was previously termed animal-type melanoma. Histologically PEMs are heavily pigmented spindled and epithelioid dermal melanocytic tumors with ...
The hair follicle bulge, which contains melanocyte stem cells, was also refractory to melanomagenesis. These studies identify varying tumor susceptibilities within the melanocytic lineage, highlighting pigment-producing cells as the melanoma cell of origin, and indicate that regional variation in tumor ...
The Case 1 tumor was in continuation with the outer root sheath of the hair follicle in the bulge region. Case 2 arose in an intradermal melanocytic nevus. Rare mitotic figures, including atypical mitotic figures, were identified in both cases. We present two cases of PEM, with histologic ...