Cardiac cell therapy: The puzzle is waiting to be solved Cell therapy has been proposed as an innovative hypothesis to treat acute myocardial infarction and heart failure. However, the mechanism by which stem cel... M Canepa,D Coviello,F Chiarella - 《Giornale Italiano Di Cardiologia》 被引量...
The article by Marion Wencker et al in this issuenof CHEST (see page 737) fits another piecenwithin the yet-unfinished jigsaw puzzle of the patho-nphysiology and treatment of a1-antitrypsin (AAT)ndeficiency. The molecular and cellular mechanismsnleading to this deficiency are among the best ...
What Is the Economic Value of Digoxin Therapy in Congestive Heart Failure Patients? Results From the DIG Trial The Digitalis Investigation Group (DIG) clinical train randomized 6800 congestive heart failure patients (ejection fraction 鈮 45%) to a daily regimen of ei... EL Eisenstein,S Yusuf,V...
This document attempts to address the relationship between COVID-19 infection and type 2 diabetes mellitus. To this end, we will briefly analyse whether the epidemiological data support this association and, subsequently, go in depth on the pathophysiological mechanisms that might connect the two ...
If confirmed, this mirrors some results from genome-wide SNP analyses, although there has been no overlap of the identified loci thus far. Implications for risk prediction and therapy Hereditary breast cancer represents a challenge in terms of genetic counselling as well as preventive and therapeutic...
The puzzle of somatostatin: action, receptors, analogues and therapy The scientific search for the revelation of the multiple physiological aspects of somatostatin has already begun. Investigators have managed to clarify man... V Panteris,DG Karamanolis - Hepato-gastroenterology 被引量: 32发表: 2005...
The desired therapeutic effect of a gene therapy also guides promoter selection. Promoters, which are the DNA regulatory sequences that control in which cells a gene is expressed, can be chosen based on tissue specificity, whether they are constitutively active or respo...
The article comments on two trials from the Adjuvant Breast Cancer Trials Collaborative Group which provide important information regarding adjuvant therapy for women with breast cancer although their interpretation is impeded by the lack of estrogen receptor measurements in more than 40% of patients. ...
p>The past year provided strong evidence on the use of the instantaneous wave-free ratio to determine the severity of coronary artery disease, the improving outcomes of contemporary percutaneous coronary intervention, the increased risk of thrombosis with bioresorbable vascular scaffolds, and the benefits...
Palfi, S. Towards gene therapy for Parkinson's disease. Lancet Neurol. 7, 375–376 (2008). Article PubMed Google Scholar Gasmi, M. et al. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease....