We rely on the firing characteristics of our spinal motoneurons to produce force, and so, to perform daily activities such as regulating pedal force while driving, walking up the stairs or lifting heavy boxes. Motoneuron firing is not solely determined by ionotropic synaptic input, but also by...
When applied iontophoretically to cat cortical neurons stimulated with glutamate, I4AA inhibited neuronal firing in a manner similar to GABA [62], but with a slower onset [63]. Roberts and Simonsen [64] found that I4AA had sedative and analgesic effects when injected ip (4 µg/g) into...