In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with different concentrations of picrasidine I (20, 30, and 40 μM) for 24, 48, and 72 h. The findings revealed that picrasidine I reduced the cell viability in a ...
HANSIZHUANG was launched in March 2022 and has been approved by the NMPA for the treatment of MSI-H solid tumours, squamous non-small cell lung cancer (sqNSCLC), extensive-stage small cell lung cancer (ES-SCLC) an...
Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck Pan-PI3K inhibition Agents that target all four class IPI3Kisoforms, includingbuparlisib(BKM120; Novartis Pharmaceuticals Corporation, East Hanover, NJ) and PX-866 (Oncothyreon, Seattle, WA), are currently under...
描述Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor su...
CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest. J. Transl. Med. 15, 127 (2017). Article Google Scholar Zhang, P. et al. A phase 1 study of dalpiciclib, a cyclin-dependent...
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated tumor suppres...
CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest. J Transl Med. 2017;15(1):127. Published 2017 Jun 2.Dalpiciclib物理化学性质 分子式 C25H30N6O2 分子量 446.54 外观性状 固体 储存...
Jiayuan Wang, et al. CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest. J Transl Med. 2017 Jun 2;15(1):127. Fei Long, et al. Preclinical characterization of SHR6390, a novel CDK...
Epithelial rest of Malassez, dental lamina and dental follicle epithelium represent potential suspects [2]. Its nomenclature and definition have changed over time: “intraosseous epidermoid carcinoma” [3],” primary intraosseous odontogenic carcinoma” [4], “primary intraosseous squamous cell carcinoma”...
EBC-1, a human lung squamous cell carcinoma line, was purchased from the Japanese Collection of Research Bioresources and both A549, a human lung carcinoma cell line and U87-MG, a human glioblastoma cell line, was obtained from the European Collection of Cell Cultures. All cell lines were cu...