The combined use medical therapy which includes the CDK4/6 inhibiter and the PI3K inhibiter for using in remedying of the cancerCombination of CDK4/6 inhibiter and P3 kinase inhibiter for remedy of cancer.キム,スンキュドシ,シヴァン...
SNPs in FGFR2 are mostly identified. However, the association between PI3KCA SNP and breast cancer risk remains largely unknown. The aim of this study was to investigate the significance of FGFR2 and PI3KCA genetic variants in breast cancer and their association with prognosis. We performed ...
PELI1 promoted PTC cell proliferation and migration, which was associated with the activation of PI3K-AKT signaling pathway. Notably, PELI1 was inversely regulated by miR-30c-5p and was a direct functional target of miR-30c-5p in PTC. Moreover, miR-30c-5p could be incorporated by human...
PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3 PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. Neuropsychopharmacology 37: 2671-... HS Shi,WL Zhu,JF ...
Aberrations in BCR-ABL independent downstream signaling pathways, namely PI3K/AKT, p53, NF-kB and Fanconi anaemia (FA)/BRCA, have been implicated. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression and are notoriously promiscuous, with one miRNA regulating many mRNAs. In ...
30 PARATHYROID HORMONE-RELATED PROTEIN INDUCES CELL SURVIVAL IN HUMAN RENAL CELL CARCINOMA THROUGH THE PI3K/AKT PATHWAY: EVIDENCE FOR A CRITICAL ROLE FOR I... We have recently shown that parathyroid hormone-related protein (PTHrP), a cytokine-like polyprotein, is critical for human renal cell ca...
The current study tests the hypothesis that GPR30 reduces myocardial infarct area and fibrosis in female ovariectomized (OVX) mice by activating the PI3K/AKT pathway.Wang, XiaowuLu, LinheTan, YanzhenJiang, LiqingZhao, MinggaoGao, ErheYu, ShiqiangLiu, Jincheng...
Massfelder, Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B, Carcinogenesis 28 (2007) 1893-1901....
Originally developed for cancer treatment, these second generation mTORC1/2 and PI3K/mTOR inhibitors show brain penetrance and efficacy in cell models of HD, making them candidate molecules for further investigations in HD.doi:10.1016/j.neuropharm.2019.107812Singer, Elisabeth...
Wei Y, Zhang Z, Liao H, Wu L, Wu X, Zhou D, Xi X, Zhu Y, Feng Y(2012): Nuclear estrogen receptor- mediated Notch signaling and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation. Oncology Reports 27:504-510...