化合物 PI3K-IN-30化学性质 沸点: 651.6±65.0 °C(Predicted) 密度: 1.46±0.1 g/cm3(Predicted) 酸度系数(pKa): 14.36±0.10(Predicted) 形态: Solid 颜色: White to off-white 安全信息 化合物 PI3K-IN-30性质、用途与生产工艺 化合物 PI3K-IN-30上下游产品信息 ...
MCE 国际站:PI3K-IN-30 产品活性:PI3K-IN-30 (compound 6d) 是一种有效的 PI3K 抑制剂,对于 PI3Kα、PI3Kβ、PI3Kγ 和 PI3Kδ,IC50 分别为 5.1 nM、136 nM、30.7 nM 和 8.9 nM。 研究领域:PI3K/Akt/mTOR 作用靶点:PI3K 相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Ak...
Originally developed for cancer treatment, these second generation mTORC1/2 and PI3K/mTOR inhibitors show brain penetrance and efficacy in cell models of HD, making them candidate molecules for further investigations in HD.doi:10.1016/j.neuropharm.2019.107812Singer, Elisabeth...
The goal of this study was to investigate the effect of G protein-coupled receptor 30 (GPR30) on the activation of PI3K/Akt pathway induced by E2 in endometrial cancer cells. Methods and materials Immunohistochemistry was performed to determine the location and expression of GPR30, estrogen recep...
PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. KOO,Byung-Soo,LEE,... - 《Biological & Pharmaceutical Bulletin》 被引量: 80发表: 2004年 PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant...
PELI1 promoted PTC cell proliferation and migration, which was associated with the activation of PI3K-AKT signaling pathway. Notably, PELI1 was inversely regulated by miR-30c-5p and was a direct functional target of miR-30c-5p in PTC. Moreover, miR-30c-5p could be incorporated by human...
Transwell assay and Western blot was used to detect the invasiveness, the expression of integrin β3 and the activation of PI3K/Akt pathway of HCC cells pretreated with IL-8 knockdown or exogenous IL-8.IL-8, integrin αv and integrin β3 were overexpressed in highly metastatic HCC cell ...
Corrigendum to Overview of the relevance of PI3K pathway in HR-positive breast cancer: Annals of Oncology, Volume 30, Issue Supplement 10, Pages x3-x11doi:10.1016/j.annonc.2020.01.067N. VasanE. ToskaM. ScaltritiAnnals of Oncology
Youji FengSpandidos PublicationsWei Y, Zhang Z, Liao H, Wu L, Wu X, Zhou D, et al. Nuclear estrogen receptor-mediated Notch signal- ing and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation. Oncology reports. 2012; 27(2):504-10. Epub 2011/11/...
Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions ... NJ Dar,NK Sa...