化合物 PI3K-IN-30化学性质 沸点: 651.6±65.0 °C(Predicted) 密度: 1.46±0.1 g/cm3(Predicted) 酸度系数(pKa): 14.36±0.10(Predicted) 形态: Solid 颜色: White to off-white 安全信息 化合物 PI3K-IN-30性质、用途与生产工艺 化合物 PI3K-IN-30上下游产品信息 ...
MCE 国际站:PI3K-IN-30 产品活性:PI3K-IN-30 (compound 6d) 是一种有效的 PI3K 抑制剂,对于 PI3Kα、PI3Kβ、PI3Kγ 和 PI3Kδ,IC50 分别为 5.1 nM、136 nM、30.7 nM 和 8.9 nM。 研究领域:PI3K/Akt/mTOR 作用靶点:PI3K 相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Ak...
2021年,恒瑞医药罕见地开启license in模式,其买下的第一款产品,是璎黎药业的PI3K抑制剂。能被老大哥一眼看上,PI3K抑制剂必然有魔力。 的确,作为发现超过30年的信号通路,PI3K(磷脂酰肌醇3-激酶)可能是扼住肿瘤的关键:在多个癌种中,都发现了PI3K信号通路异常激活。 广谱性质,作用范围广,市场期待必然不会太低。2014...
Youji FengSpandidos PublicationsWei Y, Zhang Z, Liao H, Wu L, Wu X, Zhou D, et al. Nuclear estrogen receptor-mediated Notch signal- ing and GPR30-mediated PI3K/AKT signaling in the regulation of endometrial cancer cell proliferation. Oncology reports. 2012; 27(2):504-10. Epub 2011/11/...
PELI1 promoted PTC cell proliferation and migration, which was associated with the activation of PI3K-AKT signaling pathway. Notably, PELI1 was inversely regulated by miR-30c-5p and was a direct functional target of miR-30c-5p in PTC. Moreover, miR-30c-5p could be incorporated by human...
We intend to use a novel anti-GRP78 monoclonal antibody (MAb159) to attenuate PI3K signaling and inhibit tumor growth and metastasis. EXPERIMENTAL DESIGN: MAb159 was characterized biochemically. Antitumor activity was tested in cancer cell culture, tumor xenograft models, tumor metastasis models, and...
The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the protein phosphatase 2C (PP2C) family and controls cell cycle checkpoints in response to DNA damage. p38 MAPK and ATM were identified as physiological substrates of Wip1, and we previously reported a substrate...
Nuclear estrogen receptor- mediated Notch signaling and GPR30-mediated PI3K/ AKT signaling in the regulation of endometrial cancer cell proliferation [ J ]. Oncol Rep,2012,27 (2) :504-510.Wei Y, Zhang Z, Liao H, et al. Nuclear estrogen receptor-mediated Notch signaling and GPR30-mediated ...
The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its expression patterns and functional importance in papillary thyroid cancer (PTC) remains unknown. PELI1 expressi
However, ROCK2 was a target gene of miR-30c-5p, and the effects of miR-30c-5p mimic on cell proliferation, apoptosis and EMT were reversed by ROCK2 upregulation in vitro . Furthermore, the pathogenesis of DN was regulated by the miR-30c-5p/ROCK2 axis via the PI3K/AKT pathway. ...