Shi B, Han J. Cyclic Mechanical Stretch Ameliorates the Degeneration of Nucleus Pulposus Cells through Promoting the ITGA2/PI3K/AKT Signaling Pathway. Oxid Med Cell Longev. 2021 Mar 16;2021:6699326. doi: 10.1155/2021/6699326. PMID: 33815660; PMCID: PMC7990548. ...
原名:Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K/AKT signaling pathway 译名:甘草黄酮通过PI3K/AKT信号通路抑制细胞凋亡,改善乙醇性大鼠胃溃疡 期刊:Journal of Ethnopharmacology IF:5.4 发表时间:2024.01 通讯作者:刘强&朱红霞 通讯作者单位:南方医科大学 实验...
英文标题:Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling pathway 中文标题:芍药苷与VEGFR2结合,通过PI3K/AKT信号通路恢复自噬和抑制凋...
进一步研究发现,褪黑素可以通过激活PI3K/Akt信号通路上调MT1和MT2的表达,RNA-seq分析发现共表达20486个基因。在5180个差异表达基因(DEGs)中,其中2556个基因表达上调,2624个基因表达下调。KEGG pathway 分析发现这些通路中与脂肪代谢相关的通路较多,例如MAPK(丝裂原活化蛋白激酶,Mitogen-activated protein kinase)和 PI3K...
参考文献: Jiang, T., et al., CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer. Mol Cancer, 2021. 20(1): p. 167.
17. Rosen E. Y. et al. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron 71, 1030–1042 (2011). 18. WangX.Q.et al. CDK1-PDK1-PI3K/Akt signaling...
(mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) growth, survival, proliferation, and angiogenesis, which could be an interesting therapeutic target. This review summarizes the PI3K/AKT/mTOR signaling pathway activation mechanism in TNBC and...
Xue C, Li G, Lu J, Li L. Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression. Signal Transduct Target Ther. 2021;6(1):400. Published 2021 Nov 24. doi:10.1038/s41392-021-00788-w Chiarini F,Falà F,Tazzari PL, et al. Dual inhibition of class IA phosph...
cells, which is of some significance in maintaining the steady state of human bone. In this paper, the role of this signaling pathway in bone-forming cell differentiation and bone-breaking apoptosis is explored, and the mechanism of regulating bone metabolism in the PI3K/AKt signaling pathway ...
Xue C, Li G, Lu J, Li L. Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression. Signal Transduct Target Ther. 2021;6(1):400. Published 2021 Nov 24. doi:10.1038/s41392-021-00788-w Chiarini F,Falà F,Tazzari PL, et al. Dual inhibition of class IA phosph...