参考文献:Wang D, Chen Y, Cao S, Ren P, Shi H, Li H, Xie L, Huang W, Shi B, Han J. Cyclic Mechanical Stretch Ameliorates the Degeneration of Nucleus Pulposus Cells through Promoting the ITGA2/PI3K/AKT Signaling Pathway. Oxid Med Cell Longev. 2021 Mar 16;2021:6699326. doi: 10.1155...
PF通过靶向VEGFR2介导的PI3K/AKT途径恢复自噬,抑制细胞凋亡,改善DKD大鼠肾脏损伤,为PF治疗DKD提供了理论依据。 文章信息 英文标题:Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic...
Western blot分析显示凋亡前Bax蛋白表达水平上调;而抗凋亡BCL-xL蛋白在A549细胞系中表达下调，Calu-3细胞系中表达下调。因此，我们推测Pec通过诱导NSCLC肿瘤细胞凋亡及凋亡相关蛋白表达水平来表现出抗肿瘤作用。Figure 5. Pec induces apoptosis through the PTEN/PI3K/AKT signaling pathway.Western blotting检测Pec对A549...
进一步研究发现,褪黑素可以通过激活PI3K/Akt信号通路上调MT1和MT2的表达,RNA-seq分析发现共表达20486个基因。在5180个差异表达基因(DEGs)中,其中2556个基因表达上调,2624个基因表达下调。KEGG pathway 分析发现这些通路中与脂肪代谢相关的通路较多,例如MAPK(丝裂原活化蛋白激酶,Mitogen-activated protein kinase)和 PI3K...
LC3表达显著下调,HK2细胞凋亡明显增加。结论:CLP肾脏损伤发生时可以诱导自噬发生,PI3K/Akt信号通路 在其中发挥重要调节作用。 [关键词] 自噬;PI3K/Akt通路;脓毒症;肾损伤 [中图分类号] R692.6 [文献标志码] Adoi:10.3969/j.issn.10004718.2014.06.016 PI3K/Aktsignalingpathwayregulatesautophagyinducedbyacutekid ney...
近日,来自安徽医科大学药学院的研究者们在Int J Biol Sci杂志上发表了题为“NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease”的文章,该研究表明NUP85通过调节PI3K/AKT信号通路缓解非酒精性脂肪肝的脂质代谢和炎症。
对羟基苯甲酸丁酯通过下调PI3K-AKT通路诱导斑马鱼肾损伤 文献:Huang L, Xu J, Jia K, Wu Y, Yuan W, Liao Z, Cheng B, Luo Q, Tian G, Lu H. Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway. J Hazard Mater. 2024 Mar 29;470:134129. doi...
参考文献: Jiang, T., et al., CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer. Mol Cancer, 2021. 20(1): p. 167.
signaling pathway mutations. In addition, current clinical trials, which addressed PI3K inhibitors combined with AR, PARP, CDK4/6 inhibitors and immunotherapy, have shown some efficacy. Consequently, the subsequent clinical study design could be based on PI3K/AKT/mTOR signaling pathway-related ...
WANG W T,XU Y,SHAO M H.Research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy[J].Shanghai J Tradit Chin Med, 2023, 57(1...