生化机理 PIK-75 Hydrochloride 是 PIK-75 的盐酸盐形式,是一种优先 p110α/γ 形式的 PI3K 抑制剂,对 p110α、p110β、p110γ、p110δ 的 IC50 分别为 6、1300、76、510 nM。PIK-75 是一种 PI3K p110α 特异性抑制剂,属于咪唑并[1, 2-a]吡啶类。它能在体外抑制 A375 细胞的增殖(IC50=58nM)...
3045PI 3065PI3K inhibitor (p110 δ specific)€100.00 3055B591Potent, specific class I PI3K inhibitor€125.00 2607YM201636Selective inhibitor of PIKfyve (type III PtdInsP kinase)€65.00 3794Urolithin AInhibitor of the PI3K/AKT/mTOR pathway€70.00 ...
生化机理PIK-75 Hydrochloride 是 PIK-75 的盐酸盐形式,是一种优先 p110α/γ 形式的 PI3K 抑制剂,对 p110α、p110β、p110γ、p110δ 的 IC50 分别为 6、1300、76、510 nM。PIK-75 是一种 PI3K p110α 特异性抑制剂,属于咪唑并[1, 2-a]吡啶类。它能在体外抑制 A375 细胞的增殖(IC50=58nM),...
ADP-Glo™ Kinase Assay Application Notes LIPID KINASE SERIES:PI3K(p110α/p85α) PI3K(p110α/p85α) Kinase Assay By Jacquelyn Hennek, M.S., Jolanta Vidugiriene, Ph.D., Said A. Goueli, Ph.D., and Hicham Zegzouti, Ph.D., Promega Corporation Scientific Background: Phosphatidylinositol ...
p110-alpha p85-ALPHA 产品介绍: 产品说明 一般描述 The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110 alpha catalytic subunit (PIK3CA) is frequent...
本研究采用免疫组化方法检测胃癌及正常胃黏膜组织中EGFR、PI3Kp110α和PI3Kp110β的表达情况,分析其表达与胃癌临床病理因素的关系及EGFR与PI3Kp110α、PI3Kp110β表达的相关性,评价EGFR、PI3Kp110α和PI3Kp110β的表达对胃癌患者预后的意义。 引用本文 PERMISSIONS Request permissions for this article from CCC....
PIK 75 | PI3K p110 alpha 抑制剂 英文名称: PIK 75 | PI3K p110 alpha 抑制剂 总访问: 519 国产/进口: 进口 半年访问: 8 产地/品牌: axon 产品类别: 生化试剂 规格: Axon1334 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Combined HER2 and p110α inhibition effectively reduced PI3K/AKT signaling and growth of cancer cells both in vitro and in vivo. Addition of the p110β inhibitor to dual HER2 and p110α inhibition induced tumor regression in a xenograft model of HER2+/PTEN-deficient human cancers. Together, ...
This function is probably due to the ability of Bcl-2 to regulate actin polymerization in a way that inhibits cell migration. Moreover, Bcl-2 may be differentially regulated by PI3K depending on the presence of WT or MUT p110α that may activate distinct signaling pathways and differentially ...
这种募集可以使p85–p110二聚体去抑制,并与胞膜中的脂质底物结合。一项研究通过质谱方法和具有内源性标记IA类亚基的小鼠模型进行实验表明,p85α和p85β与p110α和p110β等效结合,而p85α优先与p110δ相互作用。同时,该研究还为存在不与p110结合...