类似的,课题组观察到经共培养后,MSR1-/-小鼠来源的巨噬细胞中的M2型巨噬细胞的数量要显著少于相应对照组。 在机制探索上,课题组揭示了经共培养后,巨噬细胞的MSR1可激活PI3K/AKT/GSK3β/β-catenin通路。该通路的激活一方面可正性...
PI3K/AKT/GSK3β/β-catenin通路成骨分化目的从MC3T3-E1小鼠前成骨细胞中PI3K/Akt/GSK3β/β-catenin信号通路的角度,揭示锁阳多糖(cynomorium songaricum polysaccharide,CSP)的促成骨分化机制.方法使用含有不同浓度CSP的成骨诱导液培养MC3T3-E1细胞,在第1,3,5,7天采用MTT法检测细胞活力.随后分为Con组(0μg/m...
PI3K)-gamma Rabbit pAb抗体、Anti-蛋白激酶B2(protein kinase B2, AKT2)Rabbit pAb抗体、Anti-BMP-2 Rabbit pAb抗体、Anti-VEGF-A Rabbit pAb抗体、Anti-整合素β2亚基(Integrin beta-2,CD11b)Rabbit
PI3K/Akt/GSK‐3β/β‐catenin signalingPOTEEproliferationTo explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer ...
此外,Sun等[29]通过构建镁离子、锶离子及不同矿化胶原组合体系,证实镁离子能通过激活PI3K/AKT/GSK3β/β-catenin信号通路上调BMP-2表达,促进成骨细胞的分化和骨愈合。Zhang等[30]研究发现,镁离子通过激活TRPM7/PI3K信号通路显著促进VEGF表达,增强成骨细胞迁移能力,从而改善骨修复效果。本研究进一步验证了镁离子通过...
ENKUR also significantly down regulated PI3K and reduced p-Akt levels [74]. PI3K/AKT/GSK3β axis Glycogen Synthase Kinase 3 Beta (GSK-3β) is a downstream target of PI3K/AKT and Extracellular Signal-Regulated Kinase (ERK) signaling pathways that can be inhibited by AKT or ERK [75]. ...
ENKUR also significantly down regulated PI3K and reduced p-Akt levels [74]. PI3K/AKT/GSK3β axis Glycogen Synthase Kinase 3 Beta (GSK-3β) is a downstream target of PI3K/AKT and Extracellular Signal-Regulated Kinase (ERK) signaling pathways that can be inhibited by AKT or ERK [75]. ...
cells via activating the P2X7R that stimulated the PI3K/AKT/GSK-3β/β-catenin axis. ATP and BzATP triggered the P2X7R to down regulate CDH1, while up regulated the fibronectin, Snail, and Vimentin. P2X7R also phosphorylated GSK-3β and AKT and increased the growth of CRC cells [43]. ...
ATP and its analogs, BzATP, induced the growth and EMT of CRC cells via activating the P2X7R that stimulated the PI3K/AKT/GSK-3β/β-catenin axis. ATP and BzATP triggered the P2X7R to down regulate CDH1, while up regulated the fibronectin, Snail, and Vimentin. P2X7R also phosphorylated ...
We summarize the regulation of numerous major targets correlated with the PI3K/AKT pathway, which is further related to MDR, including the expression of apoptosis-related protein, ABC transport and glycogen synthase kinase-3 beta (GSK-3β), synergism with nuclear factor kappa beta (NF-κB) and...