PI3K/AKT pathwayHEARTINSULINMYOCARDIUMBUFFER solutionsINSULIN therapyRATSInsulin exerts positive inotropic effects on cardiac muscle; however, the relationship between cardiac contractility and phosphoinositol-3-kinase/Akt (PI3K/Akt) activation remains unclear. We hypothesized that the positive inotropic effects...
There are many known factors that enhance the PI3K/AKT pathway including EGF,shh, IGF-1, insulin, and CaM. mTOR / PI3K / AKT通路是细胞内重要的信号通路,可以调节细胞周期。 mTOR / PI3K / AKT通路直接关系到细胞静息,细胞增殖,癌症发生和细胞生命长短。 PI3K磷酸化后活化并在细胞膜上通过磷酸化激活AK...
Insulin首先结合细胞表面受体通过IRS1激活PI3K-AKT通路，AKT直接促进Glucose的吸收，同时通过AKT-TSC1/2-R...
PDK-1:phosphoinositide-dependent kinase-1,磷酸肌醇依赖性激酶-1; AKT:是一种丝氨酸/苏氨酸特异性蛋白激酶,在多种细胞过程中发挥关键作用,如葡萄糖代谢,细胞凋亡,细胞增殖,转录和细胞迁移; TEC family kinases:Tec家族激酶,参与细胞因子受体,淋巴细胞表面抗原,异源三聚体G蛋白偶联受体和整联蛋白分子的细胞内信号传导...
结论:我们的研究结果表明CDRs可以调节Hep3B细胞中的AKT通路。由于在其他HCC和肝细胞细胞系中未观察到CDRs,我们认为Hep3B中的CDRs可能通过异常触发AKT通路来决定细胞的癌特征。参与CDR形成的信号分子是某些类型HCC有希望的治疗靶点。 Insulin(Abmole,M9194)中文名为胰岛素,是一种多肽激素,其调节血液中的糖(葡萄糖)...
结论:我们的研究结果表明CDRs可以调节Hep3B细胞中的AKT通路。由于在其他HCC和肝细胞细胞系中未观察到CDRs,我们认为Hep3B中的CDRs可能通过异常触发AKT通路来决定细胞的癌特征。参与CDR形成的信号分子是某些类型HCC有希望的治疗靶点。 Insulin(Abmole,M9194)中文名为胰岛素,是一种多肽激素,其调节血液中的糖(葡萄糖)...
The exact modulation mechanisms of the PI3K/AKT pathway in reversing MDR in a specific manner in tumor cells to lock their growth and metastasis, and induce apoptosis must be deeply investigated in the future. Introduction Although important advances in the field of chemotherapy have lowered the mo...
Lawlor MA, Alessi DR. PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?J Cell Sci2001;114: 2903–2910. Google Scholar Wang Q, Somwar R, Bilan PJ,et al. Protein kinase /Akt participates in GLUT4 translocation by insulin in L6 myoblasts.Mol Cell Biol1999;19:...
The expression levels of insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells were all partially activ...
2、PI3K/AKT 的结构特点、相关信号转导机制及其与心力衰竭的关系将有利于更好地理解心力衰竭的发病机制。关键词:心力衰竭;磷脂酰肌醇 3-激酶(PI3K);丝氨酸/苏氨酸激酶(AKT);信号通路中图分类号:R541.61 文献标识码:A 文章编号:1007-7847(2015)01-0085-06ThePI3K/AKTSignalingPathwayandHeartFailureFANLiang-liang...