Fig. 6 Receptor-mediated PI3K pathway at CDRs in Hep3B cells. AKT通过其PH结构域与细胞膜上PI3K生成的PIP3相互作用被募集到质膜。据报道,SH3YL1是一种PIP3结合蛋白,定位于小鼠胚胎成纤维细胞NIH3T3细胞中的CDRs。我们还观察到SH3YL1在Hep3B细胞中募集到CDRs(图6A)。为了确认Hep3B细胞CDRs上PIP3的生成,...
PI3K信号通路参与了细胞增殖、分化、凋亡和葡萄糖转运等多种细胞功能的调节,PI3K、Akt和mTOR是该通路的3个重要“连接点”,其中PI3K通过将PIP2转化为PIP3激活下游效应因子,在该通路中扮演着关键角色1-3(图1)。 图1 PI3K/Akt/mTOR信号通...
中文摘要 概要: 子宫内膜癌是最常见的子宫癌类型,占子宫癌病例的90%。本文通过临床研究,检测子宫内膜癌患者标本中雌激素受体(ER)和DNA复制ATP依赖性解旋酶/核酸酶(DNA2)的表达,并分析两者之间的关系。通过细胞培养实验研究ER调控DNA2表...
P13K.Akt信号通路与杆状病毒感染和昆虫细胞凋亡的关系 AcMNPVIEl增加了Sf9和Hi5细胞对ActD的敏感性。 关键词:P13K.Akt信号通路;苜蓿丫纹夜蛾核多角体病毒;细胞凋亡; Ⅲ 中山大学博士学位论文肖炜 Title:The Relationship betweenP13K-Akt SignalingPathway andBaculovirusInfectionorInsectCell Apoptosis Major:Microbiology...
PI3K-AKT-mTOR是经典的响应胰岛素信号的通路。当进食后，被分解的葡萄糖进入血液促进胰岛素的释放，胰岛素...
PI3K/AKT signaling pathway has a key role in CRC cell proliferation and migration. In the present review, we discussed the role of PI3K/AKT pathway CRC metastasis through the regulation of the EMT process. It has been shown that PI3K/AKT pathway can induce the EMT process by down regulation...
体动物模型,其分子机制可能是雷公藤甲素通过下调PI3K/AKT/mTOR信号通路 中的关键蛋白p-PI3K、p-AKT、p-mTOR而对该通路进行了抑制。补肾养血活血 中药复方新加苁蓉菟丝子丸可通过激活PI3K/AKT/mTOR信号通路改善大鼠的性 激素水平,增加大鼠的卵巢湿重和卵巢指数,恢复大鼠的各级卵泡数、黄体数及 生长卵泡的颗粒细胞层厚...
This review highlights the aberrant activation of PI3K/AKT as a key link that modulates MDR. We summarize the regulation of numerous major targets correlated with the PI3K/AKT pathway, which is further related to MDR, including the expression of apoptosis-related protein, ABC transport and ...
The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-5013 Ward SG, Finan P. Isoform-speci ?c phosphoinosit 21、ide 3-kinase inhibitors as therapeutic agents. Curr Opin Pharmacol 2003; 3: 426-4344 Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N...
2.Kang S, et, al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 Sep;17(9):989-97. 3.Aguilar-Vega L, et, al. Antibacterial properties of phenothiazine derivatives against multidrug-resistant Acinetobacter baumannii ...