PI3K/Akt/NF-kappa B pathwayThe early-life aversive experiences are associated with the increased risk for adolescent neuropsychiatric disorders and neuroinflammation. So, we used neonatal maternal deprivation (NMD) and chronic mild stress (CMS) to build adolescent depression model and investigate the ...
32.Agarwal A, Das K, Lerner N, Sathe S, Cicek M, Casey G, Sizemore N. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin.Oncogene. 2005;24:1021-1031.[PubMed] ...
显。NF-κB能够与ABCB1基因启动子区域结合。结论：阻断PI3K/AKT信号通路可增强人结肠癌HCT-116/L-OHP 耐药细胞的药物敏感性，抑制p-Akt和p-IκB的磷酸化表达水平，逆转P-gp介导的肠癌多药耐药。 ［关键词］ 结肠癌；多药耐药；P-糖蛋白；磷脂酰肌醇-3-激酶；核转录因子κB DOI: 10.3969/j.issn....
在不同的刺激下,如IL-1β,磷酸化的IκBα暴露NF-κ b复合体上的核定位信号,激活核因子NF- kappa - b p65亚基(p65)向细胞核移动,激活特定基因的转录[13,14]。NF-κ b通路在OA进展中的重要作用已被先前发表的研究证实[15,16]。 PI3K/Akt通路由丝氨酸/苏氨酸蛋白激酶家族组成,通过磷酸化p65和IκBα参与...
the region of ABCB1 gene promoter in HCT116/L-OHP cells.Conclusion:Blocking of PI3K/Akt/NF-kB signal pathway could increase the drug sensitivity to MDR cells,inhibit the phosphorylation of p-Akt and p-IκB,and reversing ABCB1/P-glycoprotein–mediated multidrug resistance in colon carcinoma ...
PI3K/AKT pathway also activates the NF-κB signaling through κBα (IκBα) protein phosphorylation [136]. CXCL8 increased the growth and invasion of CRC cells. CXCL8 induced EMT through the PI3K/AKT/NF-κB pathway by PI3K and NF-κB phosphorylations. Moreover, CXCL8 triggered EMT by ...
核因子κB (nuclear factor kappa-B,NF-κB)一直被认为是一种原型促炎信号通路,主要调控促炎基因(包括细胞因子、趋化因子和黏附分子)的表达。研究表明,NF-κB在正常视网膜中不激活,但在DR中被激活,血糖越高,时间越长,NF-κB的活性越高。PI3K/AKT/NF-κB信号通路的抑制可以使小胶质细胞失活,从而导致DR大鼠视网...
在 CVB3 的感染过程中,激活的 PI3K-Akt 信号通路,将 NF-κB 转运至细胞核并激活,同时伴 随着 caspase-9 和 caspase-3 的延迟激活,进而抑制 细胞凋亡, 促进宿主细胞存活 .[33,42,43] 通过 Akt 的显性抑制突变(dominant negative mutant)或抑制 PI3K-Akt 信号通路则均可促进 CVB3 感染细胞的凋 亡[31].与...
NF-kB:nuclear factor kappa B PI3K:phosphatidylinositol 3-kinase PIP2:phosphatidylinositol 4,5-bisphosphate PIP3:phosphatidylinositol (3,4,5)-trisphosphate CLL:chronic lymphocytic leukemia FL:follicular lymphoma SLL:small lymphocytic lymphoma 参考文献: 1.PI3K Inhibitors: UnderstandingToxicity Mechanisms and ...
46、sion in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene 2005; 24: 1021-1031Chandrasekar N, Mohanam S, Gujrati M, Olivero WC, Dinh DH, Rao JS. Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells. Oncogene 2003; 22: 392...