PI3K/AKT信号通路虽然与癌症的发生发展有关,但在正常组织修复过程中至关重要,并在损伤组织的再生、重构和再上皮化中发挥关键作用。PI3K/AKT信号通路失调对伤口愈合有显著影响。 PI3K/AKT信号通路开启或关闭一些下游调控蛋白,包括哺乳动物雷帕霉素靶蛋白(mTOR)和糖原合酶激酶3 (GSK3)。AKT磷酸化mTOR和GSK3影响多种...
PI3K/AKT信号通路开启或关闭一些下游调控蛋白,包括哺乳动物雷帕霉素靶蛋白(mTOR)和糖原合酶激酶3 (GSK3)。AKT磷酸化mTOR和GSK3影响多种生物活性,如增殖、生长和生存。mTOR激活失调导致与糖尿病和心血管疾病相关的并发症,而磷酸化依赖于GSK3亚型的抑制;GSK3 β (β)和GSK3 α (α)通过AKT调控包括糖原合成酶(GS...
AKT can do phosphorylation of GSK3β to inhibit its activity, thereby promoting the glucose metabolism and regulating of cell cycle. AKT can phosphorylate the TSC 1/2 (tuberous sclerosis complex), being able to prevent its negative regulation on small G protein Rheb (Ras homology enriched in ...
PDK1. 仅能使 Thr308 位点磷酸化,但 Akt 的 PH 区可与脂质产物结合,形成 PDK1/PDK2复合体,从而使得 Akt 能通过 PDK2对其Ser473位点的磷酸化而被激活。活化的Akt进一步激活或抑制下游Bad、Caspase-9、NF-xB和GSK-3β等靶蛋白,调节细胞生理过程。
别名: AR-A014418 抑制剂;N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲;N-(4-甲氧基苄基)-N-(5-硝基-1,3-噻唑-2-基)脲;茚草酮;GSK-3BETA 抑制剂 VIII CAS No.:487021-52-3 分子式: C12H12N4O4S 分子量: 308.31 A126821 AR-A014418,GSK-3抑制剂 ,Moligand™, ≥98%,≥98% ...
PI3K/AKT/mTOR 通路是一种细胞内信号传导通路,参与多个生物学过程,例如细胞增殖、凋亡、血管生成和葡萄糖代谢1,2。细胞外生长因子与跨膜受体酪氨酸激酶(RTK),例如 EGFR3,4,结合后会激活该通路,随后磷脂酰肌醇 3-激酶(PI3K)和丝氨酸/苏氨酸蛋白激酶 B(PKB/AKT)也被激活,从而导致一系列下游底物发生丝氨酸和/或苏...
Integrin，FAK，Paxillin，ILK，PIP3，S6，p70S6K，RTK，Gab1，Gab2，IRS-1，PI3K，PTEN，AKT，PDK1，Cytokine Receptor，Jak1，CD19，BCR，Ag，BCAP，Syk，Lyn，GPCR，TSC1，TSC2，Gβγ，GαGTP，PP2A，PHLPP，CTMP，PDCD4，4E-BP1，ATG13，mTORC1，TSC1，TSC2，PRAS40，XIAP，...
One of the most frequently altered pathways in human cancer is the PI3K-Akt-mTOR signaling pathway. Here, we describe mechanisms by which this signaling network is responsible for controlling cellular metabolism. Through both the post-translational regulation and the induction of transcriptional programs...
Abnormal activation of the Akt GSK3beta signaling pathway in peripheral blood T cells from patients with systemic lupus erythematosus[J]. Cell Cycle, 2009, 8(17):2789 2793.[11]PERL A. Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases[J]. Nat Rev Rheumatol, 2016, ...
13.Gao N, Flynn DC, Zhang Z, Zhong XS, Walker V, Liu KJ, Shi X, Jiang BH. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.Am J Physiol Cell Physiol. 2004;287:C281-C291.[PubMed] ...