We can to the conclusion that LEV may operate via the PI3K/AKT signalling pathway, with increases in PI3K, p-AKT, and BCL-2 protein and mRNA expression, so that the percentages of GC-1 spg cells apoptosis decrease, and the sperm count and motility improve.doi:10.1111/and.14290...
模型对照组大鼠 IL-1β,IL-6,TNF-α 及 MDA 水平极显著增加(P<0.01), CAT,SOD 活性及 p-PI3K,p-Akt,p-mTOR 蛋白表达极显著降低(P<0.01);与模型对照组比较,刺五加多糖 低,高剂量组大鼠 IL-1β,IL-6,TNF-α 及 MDA 水平显著降低(P<0.05,P<0.01),CAT,SOD 活性及 p-PI3K, p-Akt,p-mTOR ...
然而,Bmp7在精原细胞中是否激活PI3K/AKT信号通路;Sohlh1是否通过Bmp7激活PI3K/AKT信号通路,进而发挥促进精原细胞增殖的作用,以上问题尚不清楚.基于以上,本课题拟利用Sohlh1基因敲除小鼠和GC-1 spg精原细胞系,在动物和细胞实验中探讨SOHLH1蛋白对Bmp7的转录调控作用,及对PI3K/AKT信号通路的影响,阐明Sohlh1影响精...
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