PI3K/AKT信号通路是一条重要的细胞内信号传导途径,其中约60%的乳腺癌会过度激活PI3K/AKT通路,在促进细胞增殖、抑制细胞凋亡等病理过程中具有重要作用[20-22]。本研究采用免疫组化方法检测良性乳腺病变、无LNM以及LNM组织中PI3K、磷酸化p-...
Anti-PD-L1 monoclonal antibodyAutophagyPI3K/AKT/mTORPulmonary fibrosisPulmonary fibrosis is a fatal lung disease for which no effective treatment is available. Previous studies have shown that the expression of programmed cell death-Ligand (PD-L1) is significantly increased in pulmonary fibrosis, and ...
AA331 Phospho-Akt(Thr308)抗体(兔多抗) >10次 683.00元 加入购物车 AF0042 AFP Rabbit Polyclonal Antibody 50μl 563.00元 加入购物车 AF0045 Akt1 Mouse Monoclonal Antibody 50μl 482.00元 加入购物车 AF0258 p70 S6 Kinase β Rabbit Polyclonal Antibody 50μl 636.00元 加入购物车 ...
用100nM Akt抑制剂MK-2206抑制Akt激活可以显著消除AT1R和ETAR-IgG对 HMEC-1s损伤修复的阻碍作用(图3),这表明AT1R和ETAR-IgG通过激活Akt阻碍HMEC-1s损伤修复。 图3. AT1R和ETAR-IgG通过激活Akt阻碍HMEC-1s损伤修复 Akt通常促进细胞增殖和迁移[15...
PI3K-Akt signaling pathway among the top 50 enriched pathways (with the top 20 enriched pathways shown in Fig.4B). In addition, by querying Human Autophagy Database (http://www.autophagy.lu/index.html) with these above DEGs, we noticed that 21 (4 downregulated and 17 upregulated) could ...
Overexpression of METTL14 not METTL3 reversed high glucose-activated Akt pathway and HDAC5 expression via PTEN. Finally, in vivo administration of TSA reduced HDAC5 expression and extracellular matrix (ECM) accumulation in the kidneys of diabetic mice. Materials and methods Materials Primary antibody ...
Only one of the PI3K-AKT-regulated KSRP targets, hnRNPA/B, is very weakly immunoprecipitated by anti-AUF1 antibody (Figure 1C and Additional file 5). Conversely, anti-hnRNPA1 antibody efficiently immunoprecipitates KSRP target transcripts (Figure 1C). Both AUF1p45 and hnRNPA1 bind very weakly...
本品是一种常用的phosphatidylinositol 3-kinase (PI3K)抑制剂。LY294002可以通透细胞,特异性抑制PI3K,抑制PI3K/Akt信号途径,包括常见的抑制Akt磷酸化等。LY294002对于纯化的PI3K的IC50为1.4 μM。 CAS:154447-36-6 分子式:C19H17NO3 分子量:307.3 纯度:>98% ...
天津市 器官移植临床医学研究中心,天津 300192) 调节性 T 细胞(regulatory T cell,Treg)与 Th17 细胞间的相对平衡是实现器官移植术后免疫耐受的 关键因素.PI3K/Akt/mTOR 通路是调节 Treg/Th17 平衡的作用机制之一,对二者的分化,功能和增 殖均有重要影响.本文就 PI3K/Akt/mTOR 通路在 Treg/Th17 中的作用进行...
Rabbit monoclonal PI3K, phospho-PI3K, Akt and phospho-Akt antibodies were from Cell Signaling Technology (Danvers, MA, USA). Rabbit polyclonal VEGF antibody, 5-bromo-2-deoxyUridine (BrdU) and mouse monoclonal BrdU antibody were purchased from Boster Biotechnology (Wuhan, China). Isolation of rat ...