The present invention relates to imidazopyridazine compounds of Formula I, such as representative structure A, or a pharmaceutically acceptable salt thereof, that inhibit phosphoinositide 3-kinase;Shon BookerTae-Seong KimHongyu LiaoLongbin LiuMark H. Norman...
The PI3 kinase/AKT/mTOR Pathway The phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is an intracellular signalling pathway. This pathway is crucial for regulating cell cycle and directly impacts cellular proliferation, apoptosis, and cancer. Under normal...
浓度:2000 ug/ml 库存:现货 点击咨询售前客服 点击咨询售后客服 humanWB MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer. See more citations PI3 Kinase p85 Alpha Monoclonal antibody ...
- 《Cancer Cell》 被引量: 158发表: 2013年 Requirement for Interaction of PI3-Kinase p110α with \\{RAS\\} in Lung Tumor Maintenance Summary \\{RAS\\} proteins directly activate PI3-kinases. Mice bearing a germline mutation in the \\{RAS\\} binding domain of the p110α subunit of ...
2. Bader, AG et al., Nat Rev Cancer. Dec 5(12):921-9 (2005) PI3激酶 (p110α/p85α) 重组蛋白相关研究: PI3 kinase (p110α/p85α) Recombinant PI3 kinase p110α(H1047R)/p85α, FLAG-Tag Recombinant PI3 kinase p110α(E545K)/p85α Recombinant ...
gastric cancer patients. 单位定义 One unit of 110a/p85a kinase activity is defined as the amount of enzyme required to produce 1 pmol of Phosphoinositol-3, 4,5-Trisphosphate/min at 37℃. 外形 Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 ...
p110δ PI3 kinase pathway: emerging roles in cancer Class IA PI3Ks consists of three isoforms of the p110 catalytic subunit designated p110α, p110β, and p110δ which are encoded by three separate genes. Ga... N Tzenaki,EA Papakonstanti - 《Frontiers in Oncology》 被引量: 34发表:...
PI3 kinase (p110α/p85α) 重组蛋白产品数据库: 文献参考: 1. Vogt, PK et al., Virology. 344(1):131-(2006) 2. Bader, AG et al., Nat Rev Cancer. Dec 5(12):921-9 (2005) BPS Bioscience是一家通过ISO 9001:2015认证的生命科学领域的供应商,公司一直致力于开发药物研发领域的重组蛋白酶、...
M. (2006) PI3 kinases in cancer: from oncogene artifact to... JJ Zhao,TM Roberts - 《Sci Stke》 被引量: 69发表: 2006年 PI3 KINASES INHIBITORS The invention relates to the novel compounds of formula (1), which, due to their pharmaceutical effect as PI3 kinase modulators, are suitable ...
克立普/卡西9激酶淘汰力小病毒库(阵列格式) 相关服务 蛋白质生产和标签 定制重组细胞系 蛋白酶筛选和分析 PI3 kinase(p110α/p85α)重组蛋白文献参考: 1. Vogt, PK et al., Virology. 344(1):131-(2006) 2. Bader, AG et al., Nat Rev Cancer. Dec 5(12):921-9 (2005)...