particle modelscontinuum modelsCollective cell migration is a key driver of embryonic development, wound healing, and some types of cancer invasion.Here, we provide a physical perspective of the mechanisms underlying collective cell migration.We begin with a catalog of the cell–cell and cell–...
Models of collective migration are surveyed in order understand how collective metastatic invasion can occur. We conclude by contrasting cells' sensory abilities with their sensitivity to drugs, and suggesting potential alternatives to cell-death-based cancer therapies. 展开 ...
LETTERS PUBLISHED ONLINE: 3 MAY 2009 | DOI: 10.1038/NPHYS1269 Physical forces during collective cell migration 来自 Citeseer 喜欢 0 阅读量: 30 作者:X Trepat,MR Wasserman,TE Angelini,E Millet,DA Weitz,JP Butler,JJ Fredberg 收藏 引用 批量引用 报错 分享 ...
We present our automated methodology that allows directintegration of kinematic data with appropriately constrained computational models to predictphysical parameters. Such predictions can be used to direct further experiments to betterunderstand how collective migration is regulated during development and ...
Nominally identical microplastic models differ greatly in their particle-cell interactions Microplastics research is often based on commercial model particles. Here, the authors show that nominally identical particles may differ significantly in their properties and thus in their interactions with cells. ...
Photocatalytic oxidative coupling of methane is a promising approach to create muti-carbon products. Here, the authors use Ce dopants to construct electronically asymmetric lattice oxygen sites in ZnO to enhance methyl migration and promote C-C coupling. ...
(Sect.2). This is followed by a short description of the computational models of magnetic field evolution on the solar surface and interior which has shown great promise as predictive models of the solar cycle (Sect.3). Physical insights on sources of irregularities in the strength of the ...
“One can think of a central government as the central nucleus of the cell,” Kenneth said. “Imagine regional governments as the embedded mitochondria and other specialized organelles. Carrying the analogy further, a country’s borders are analogous to the cell membrane.” ...
Advances in microfluidics and microfabrication have led to the development of tissue and organ models that can incorporate physiological fluid flow and real-time optical imaging to study tumour cell migration and mechanotransduction. Microfluidics are also used to create human 'organs-on-chip' models ...
The elastic properties of a cell's substrate have been shown to guide cell migration3,4 and determine cell fate5,6. Eukaryotic cells, including fibroblasts, mesenchymal stem cells and cancer cells, attach to substrates via transmembrane protein complexes called focal adhesions, allowing the cell to...