Human meniscus progenitor cells3D cell-based constructsBiomimetic cyclic loadingGelMA hydrogelExtracellular matrixMeniscus,the cushion in knee joint,is a load-bearing tissue that transfers mechanical forces to extracellular matrix(ECM)and tissue resident cells.The mechanoresponse of human tissue resident stem...
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Meniscus tissue engineeringFibrochondrocyteA meniscus tear is a common knee injury, but its regeneration remains a clinical challenge. Recently, collagen-based scaffolds have been applied in meniscus tissue engineering. Despite its prevalence, application of natural collagen scaffold in clinical setting is...
Meniscus, the cushion in knee joint, is a load-bearing tissue that transfers mechanical forces to extracellular matrix (ECM) and tissue resident cells. The mechanoresponse of human tissue resident stem/progenitor cells in meniscus (hMeSPCs) is significant to tissue homeostasis and regeneration but ...
Non-limiting examples of bone defects can include those associated with vertebral body or disc injury/destruction, spinal fusion, injured meniscus, avascular necrosis, cranio-facial repair/reconstruction (including dental repair/reconstruction), osteoarthritis, osteosclerosis, osteoporosis, implant fixation, ...
[83] dissolved horse cartilage, meniscus, and tendon tissue after a decellular treatment to modify methacrylic anhydride and form a new composite hydrogel with GelMA and used it to culture horse chondrocytes and bone marrow mesenchymal stem cells (BMSCs). Gao et al. [84] synthesized the photo...
The microsphere loaded constructs were found to be immuno-compatible as well. Therefore, these bioactive microsphere-laden 3D printed meniscus constructs would potentially promote regeneration and integration of meniscal tissue in vivo.Ashutosh Bandyopadhyay...