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The cytochrome P450 family of enzymes (CYPs) are important targets for medicinal chemistry. Recently, CYP1B1 has emerged as a key player in chemotherapy resistance in the treatment of cancer. This enzyme is overexpressed in a variety of tumors, and is co
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After aging, the precipitates were collected by centrifugation, and washed in de-ionized water and ethanol for six times. After drying at 25 °C for 12 h, the PB crystals were obtained. CuFe PBA powder was synthesized using a coprecipitation method. Briefly, 100 mL of 0.05 M Cu(NO3)2 ...
M. Protein homeostasis and aging: taking care of proteins from the cradle to the grave. J. Gerontol. A Biol. Sci. Med. Sci. 64, 167–170 (2009). 2. Mizushima, N. et al. Autophagy fights disease through cellular self-digestion. Nature 451, 1069–1075 (2008). 3. Cuervo, A. M. ...
This toxicity range was evaluated using moderate irradiances (0.39 mW/cm² at 440 nm) and overlaps the toxic light range previously determined on RPE aging models using higher irradiances5 (1.09 mW/cm² at 440 nm). A direct cone insult may therefore prevail over the RPE cell ...