Phospholipase D Family Member 4 Regulates Microglial Phagocytosis and Remyelination via the AKT Pathway in a Cuprizone‐Induced Multiple Sclerosis Mouse Modeldoi:10.1111/cns.70111Sun, RanMa, TengyunZhao, ZhengGao, YanFeng, JuanYang, XueCNS Neuroscience & Therapeutics...
PLCβ participation has been seen in the separation by regulating cyclin D3 and other cellular activities which include proliferation via the protein kinase C (PKC)α-mediated pathway (Bavelloni et al., 2015). The PLD family can be grouped into three main types: PLD1, PLD2, and mitoPLD. ...
The phospholipase D superfamily plays a central role in a variety of functions in prokaryotes, viruses, yeast, fungi, plants, and eukaryotic species. In mammalian cells, the pathways modulating catalytic activity involve a variety of cellular signaling components, including G protein–coupled receptors...
Amongst the eight beta-1 isoforms present, two resided on chromosomes 1, 3, and 4 each, while one was situated on chromosome 7. Those located specifically on chromosomes 1, 3, and 4 were namedPgPLD-beta1-1aandPgPLD-beta1-1b, respectively, for chromosome 1;PgPLD-beta1-3aand3bfor chr...
www.cell-research.com | Cell Research npg Phospholipase D family in rice 890 A Control PA (50 µm) 70 60 50 40 * 30 20 10 0 C PA 12 10 8 6 * 4 2 0 C PA C 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0 GAmyb α-amylase SAPK8 SAPK10 B 160 140 120 100 80 60 40 20 0 D ...
(N=4 in each group). (c) Immunoblotting of phosphorylated (p-p38) and total p38 MAPK in the presence of an NFAT inhibitor (11 R-VIVIT; treated for 24 h with the concentrations indicated). β-actin was used as a loading control. Results are representative of two trials. (d, e...
Phospholipase D6 (PLD6) is a critical enzyme involved in mitochondrial fusion with a key role in spermatogenesis. However, the role of PLD6 in cancer remains unknown. Notably, Wnt signaling, energy metabolism and mitochondrial function show complex inter
PRV infection, through a mechanistic process, stimulated the induction of Toll-like receptors 2 (TLR2), 3, 4, and 5, which in turn elevated the levels of pro-IL-1, pro-IL-18, and gasdermin D (GSDMD) transcription. Our findings also indicated that PRV infection and the transfection of ...
Six, D. A. et al. Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2. J. Med. Chem. 50, 4222–4235 (2007). Article CAS PubMed MATH Google Scholar Yaksh, T. L. et al. Systemic and intrathecal effects...
1.2 mM MgSO4, 1.2 mM KH2PO4, 10 mM glucose, and 20 mM HEPES (pH 7.4) at 37°C for 10 min. The reaction was initiated by the addition of 9,11-epithio-11,12-methano-TXA2 (STA2). When carbonodithioic acid ester (d-609) was used, it was added 10 min before the addition...