signal transductionPH domainsprotein kinases.Phosphoinositides comprise a family of eight minor membrane lipids which play important roles in many signal transducing pathways in the cell. Signaling through various phosphoinositides has been shown to mediate cell growth and proliferation, apoptosis, ...
Phosphoinositides and Signal Transduction in the Cat Carotid Body The phosphoinositides, namely phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidylinositol (PI) play an influential role in intracellular signaling. Phospholipase C (PLC) hydrolyzes PIP2 and PI to produce the signaling molecules.....
Myo-inositol containing lipids play a central role in signal transduction whereby ligands on the cell surface initiate specific physiological responses. Biochemical and pharmacological aspects of the measurement of stimulated phosphoinositide turnover are reviewed, together with other recent developments concerni...
Numerous circulating and locally produced hormones bind to specific cell-surface receptors and activate a variety of second-messenger pathways that evoke characteristic phenotypic responses in their target cells. One of the most ubiquitous signal transduction mechanisms is the phosphoinositide-calcium messenger...
This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids and features contributions from some of the leading laboratories. The chapters span three key topics: the metabolism of inositol phosphates and identification of proteins that interact with ...
Phosphorylated derivatives of phosphatidylinositol (PtdIns), known as phosphoinositides (PIs), are essential regulators of nuclear functions, cytoskeletal dynamics, cell signaling and membrane trafficking. These lipids are found on the cytosolic face of intracellular membranes but can also be detected in me...
This is a review of the current opinions on lipid signalling research with an emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate, but in the light of recent research it has become appa...
This volume summarizes current research on cellular signal transduction involving inositol phosphates and phospholipids, and features contributions from some of the leading laboratories. The chapters span three key topics: the metabolism of inositol phosphates and identification of proteins that interact with...
In plants, tip-growing cells represent an ideal system to investigate signal transduction mechanisms, and among those, pollen tubes are one of the favourite models. Many signalling pathways have been identified during germination and tip growth, namely, Ca 2+ , calmodulin, phosphoinositides, cyclic ...