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1. The activities of fructose 1,6-diphosphatase were measured in extracts of muscles of various physiological function, and compared with the activities of... LH Opie,EA Newsholme - 《Biochemical Journal》 被引量: 449发表: 1967年 Fatal infantile glycogen storage disease: deficiency of phosphofruc...
In this manner, these two physically linked enzymes function to modulate the cellular concentration of F2,6BP. The importance of this regulation cannot be understated as this sugar plays an essential signaling role in regulating glucose metabolism in a variety of tissues. Perhaps most importantly, ...
(islet) β-cells, and is not inhibited by glucose-6-phosphate. The functions of glucokinase in hepatocytes and β-cells are different, and this difference is consistent with their metabolic function. During postprandial and hyperglycemic periods, hepatocyte glucose uptake is increased due to ...
When the tRNA of mammalian cells is incompletely charged due to amino acid deficiency or by analogs which cannot be activated, many metabolic events become limited. This rapid demise of cell function appears to be due to the inhibition of phosphofructokinase (PFK) by uncharged tRNA (FEBS Lett ...
correlated with AKT S473 phosphorylation and PFKP S386 phosphorylation and expression levels, highlighting the importance of the effect of loss of PTEN function on PFKP expression and aerobic glycolysis. These findings underscore the potential of PFKP as a molecular target for the treatment of human ...
averse 42 oerforms the same function as 8:33: it serves to expose a grievous misconception and by graphic language to impress the seriousness of the matter indelibly upon the disciples' hearts 诗歌42 oerforms作用和8:33一样: 它服务由图形语言暴露悲伤误解和铭记问题的重要性不可磨灭在门徒的心脏[...
Similar to the properties of gluconeogenic enzymes, these key glycolytic enzymes also have low activities and govern one-way reactions; however, they operate in the opposite direction to the function of the key gluconeogenic enzymes. A simultaneous, but antagonistic action on the key gluconeogenic ...
All nucleotidetriphosphates function as phosphate donor forming fructose 1,6-bisphosphate from fructose 6-phosphate. However, the kinetic analysis revealed distinctly differences between them. Photolabeling causes a decrease in enzyme activity to a similar extent, and ATP acts as competitive effector to ...