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In situ distribution of phosphorylated (activated) PKA (green) in adult female S. mansoni revealed using anti-phospho-PKA-C antibodies.Paulu S. R. de SaramMargarida RessurreiçãoAngela J. DaviesDavid RollinsonAidan M. EmeryAnthony J. Walker...
cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.,subunit:A number of inactive tetrameric ...
Parathyroid hormone (PTH) is an effective anti-osteoporosis agent, after binding to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the major...
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This result is consistent with our pharmacological studies, which reveal that both PP1 and PKA activities are required for AICD.doi:10.1016/j.alcohol.2018.05.001Fan YangChasity ScarbroughJoseph H. SissonMaureen WirschellAlcohol
Cytosolic phospholipase A2α (cPLA2α) up-regulation has been reported in human colorectal cancer cells, thus we aimed to elucidate its role in the proliferation of the human colorectal cancer cell line, HT-29. EGF caused a rapid activation of cPLA2α which coincided with a significant increas...
Role of PKAcα in binding of HSF1, p300 Ac-histone H4, Pol II, phospho-S2-Pol II, phospho-S5-Pol II and CDK9 to the hsp70.1 promoter at 42°C.Yue ZhangAyesha MurshidThomas PrinceStuart K. Calderwood