A phosphate group refers to a chemical group consisting of phosphorus and oxygen atoms. It is found in both DNA and RNA, where it is attached to the hydroxyl group of the sugar molecule. AI generated definition based on: Handbook of Biomolecules, 2023 ...
McNeil, The phosphate group of DNA as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer, Int. J. Radiat. Oncol. Biol. Phys. 12:1203–1206 (1986a).The phosphate group of DNA as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer - Silver, ...
DNA and RNA are composed of nucleotides that are linked to one another in a chain by chemical bonds, called ester bonds, between the sugar base of one nucleotide and the phosphate group of the adjacent nucleotide. The sugar is the 3' end, and the phosphate is the 5' end of each nuclei...
et al. Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis. J. Biol. Chem. 278, 46832–46839 (2003). Article CAS PubMed Google Scholar Ding, G. et al. Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. J. Biol. Chem. 282, 27493–...
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in signal transduction remains ...
Interestingly, when CNPs bind to plasmid DNA, no cleavage products are detected. While cerium(IV) complexes generally exhibit the ability to break phosphorus-oxygen bonds, the reactions we report appear to be dependent on the availability of cerium(III) sites, not cerium(IV) sites. We ...
rubescens. The full-length c DNA of Ir DXS encoded 722 amino acid residues with a predicted molecular mass of 77.7 KD. Sequence alignment showed that Ir DXS had high homology to known DXS proteins from other plant species and contained the conserved N-terminal plastid transit peptide,the N-...
Hydroxyalkylated phosphoramidate, phosphoramidothioate and phosphorodiamidothioate derivatives as thiophosphate protecting groups in the development of thermolytic DNA prodrugs The hydroxyalkylated phosphoramidate4a, phosphoramidothioates4b,4e–j, and phosphorodiamidothioates4cand4dhave been identified as a...
Even with the traditionally applied radiation dose of 25 kGy, the free radicals generated may have a negative impact on the patient’s health. Abnormally high concentrations of free radicals in the body have the potential to cause DNA damage and mutations, therefore leading to the development of...
The principle of calcium phosphate coprecipitation involves incubating DNA and calcium chloride in a phosphate buffer to form DNA-calcium-phosphate precipitates, which are subsequently adsorbed on the cell surface and internalized. From:Comprehensive Biotechnology (Third Edition),2019 ...