We report here that the genomic region of the PHLDA3 gene undergoes loss of heterozygosity (LOH) at a remarkably high frequency in human PanNETs, and this genetic change is correlated with disease progression and poor prognosis. We also show that the PHLDA3 locus undergoes methylation in ...
提供的PHLDA3人源重组蛋白(P01)产品为带有GST标签的人源PHLDA3全长序列重组蛋白,其对应的GeneID号为23612。 产品描述 与其它公司提供的重组蛋白不同,该PHLDA3人源全长重组蛋白(P01)产品为采用CFS的无细胞麦胚蛋白合成系统表达出来的重组蛋白,可表达出对细胞有毒性、易被蛋白酶降解的蛋白;并获得具有良好的可溶性...
以C57BL/6小鼠PHLDA3基因的cDNA为模板,用如下引物PCR扩增小鼠PHLDA3基因(NCBI,Gene ID:27280,CCDS35722.1): 上游引物:5’-AGCTTTGTTTAAACGCCACCATGACGGCGGCGGCGACCGTGCTGAAGGAGG-3’, 下游引物:5’-CTAGCTAGCTTAGGACACAAGGGTCCCAGTCC-3’。 把扩增得到的产物和pCAG-CAT-LacZ载体(北京协和医学院基础学院杨青林...
Phlda3 regulates the cytokine, oxidative and ER stress responses in beta cells via the repression of inflammatory gene expression and the maintenance of antioxidant and adaptive UPR gene expression. Phlda3 may promote beta cell survival in diabetes....
Datasheet for Goat Anti-PHLDA3 / TIH1 Antibody (EB06168) – a polyclonal antibody designed to detect protein products of the gene PHLDA3 by western blot and ELISA.
We now identify PHLDA3 as a p53 target gene that encodes a PH domain-only protein. We find that PHLDA3 competes with the PH domain of Akt for binding of membrane lipids, thereby inhibiting Akt translocation to the cellular membrane and activation. Ablation of endogenous PHLDA3 results in ...
Gene ID (NCBI) 22822 RRID AB_3672692 Conjugate CoraLite® Plus 488 Fluorescent Dye Excitation/Emission Maxima Wavelengths 493 nm / 522 nm Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q8WV24 Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3....
Using this SCC model, we show that thePHLDA3gene, a p53-target gene encoding a protein kinase B repressor, is involved in the suppression of benign and metastatic tumor development. Loss of PHLDA3 induces an epithelialmesenchymal transition and can complement p53 loss in the formation of ...
Thegene encodes a small 127 amino acid protein with a pleckstrin homology (PH)-only domain. The expression and significance of PHLDA3 in lung cancer remain unclear. Here, we investigated the role of PHLDA3 in tumor proliferation and invasion in lung adenocarcinoma. Immunohistochemistry and immuno...
GENE EXPRESSIONCELL SIGNALLINGObjective Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the ...