nitrobenzene enters the evaporator from a high level tank and is contacted with hot hydrogen for gasification, and overheat to 180~223 ℃, The mixed gas enters from the bottom of the fluidized bed and reacts with the copper catalyst supported on silica gel in the fluidized bed, and the crud...
It is known that phenylhydroxylamine reacts with nucleophilic reagents in the presence of aqueous inorganic acids to yield para substituted phenylamines. See, for example, H. E. Heller et al., Nature, 168, 1951) 909, and E. Bamberger, Justus Liebig's Annalen der Chemie, 390, 139-144 (...
In process (a), the reactants (II) and (III) are coupled together in a suitable inert solvent such as tetrahydrofuran using, for example, Mitsunobu conditions. Thus, for example, the reactants are treated with a phosphine derivative and an azo derivative at a suitable temperature, generally...
R4 and R5 are as hereinbefore defined, may be prepared by reacting compounds of formula X, where R3 is —NH2 and R2, R4 and R5 are as hereinbefore defined, with nitrous acid to give a diazo compound which is then reacted with sulphur dioxide in the presence of copper chloride, for ex...