In the process, toluene or by different substituents substituted toluene, alcohol, oxidizing agent, and carbon monoxide used as raw materials. By catalysis with complex - catalyst, which is formed from transition metal and ligand, are compounds which the structure of phenyl acetic acid esters or ...
The present invention discloses a method for preparing substituted phenylacetic acid and its ester derivatives, the method uses a variety of substituents toluene or toluene, an alcohol, an oxidizing agent and carbon monoxide as a starting material, by the formation of a transition metal and ligand...
Uses Phenylacetic Acid is used in the synthesis of Diclofenac (D436450) and its metabolite 4'-Hydroxydiclofenac (H825225), which is the principal human metabolite of Diclofenac. Definition ChEBI: A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been...
As used herein, the term “carboxylic acid surrogate” refers to those moieties that are used as surrogates for a carboxylic acid moiety. Such groups are generally known to one of skill in the art (see, for example, THE PRACTICE OF MEDICINAL CHEMISTRY; Wennuth, C. G., ed., Academic ...
METHOD FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENEPROBLEM TO BE SOLVED: To provide a method for manufacturing a substituted phenylacetic acid and ester-based derivatives thereof.HUANG HANMIN黄 漢民XIA CHUNGU夏 春穀XIE PAN解攀
In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ...
Basso A,Martin L.D,Ebert C,,Gardossi L,Linda P.Selectivity of penicillin G acylase towards phenylacetic acid derivatives in amide bond synthesis in toluene. Molecular Catalysis B . 2001Basso A,Martin L.D,Ebert C,,Gardossi L,Linda P.Selectivity of penicillin G acylase towards phenylacetic ...
A process for producing phenylacetic acid is provided. The process includes combining sodium, chlorobenzene, toluene, and a catalyst to form a suspension. This suspension is mixed to form phenylsodium. Upon boiling, the suspension forms benzylsodium. The suspension is then carbonized and acidified ...
At 340 掳C, toluene gave five 1-trifluoromethyl-substituted compounds:- -2H,4H,5H-tetrafluorocyclohexa-1,4-diene (IX); -2H-4H/5H-hexafluorocyclohex-1-ene (X); -2H-octafluorocyclohex-1-ene (IV); -nonafluorocyclohex-1-ene (III); also perfluoromethylcyclohexane (II); traces of perfluoro...
Intermediates therefor and an overall synthesis from an alcohol of the formula ROH and a toluene of the formula are also shown.