p-coumaric acid is then formed from cinnamic acid by cinnamic acid 4-hydroxylase (C4H), which catalyzes the introduction of an hydroxyl group on the phenyl ring. To form p-coumaroyl-coenzyme A (CoA), the carboxyl group of p-coumaric acid is activated by the formation of a thioester bond...
2 It is then interesting to investigate a substituent effect on this polymerization. We here describe the anionic ring-opening polymeriza- tion of 1,2,2-trimethyl-l-phenyl-l ,2-disilacyclopentane (1) (Scheme 2). A phenyl group is capable of conjugat- ing with an Si-Si bond and ...
Table 1 shows the IC50 values of (Z)-BPT derivatives and kojic acid. Table 1. The IC50 values and synthetic yields of (Z)-BPT derivatives against mushroom tyrosinase and log P values. The (Z)-BPT derivatives 8–11, with no hydroxyl group, showed no potent tyrosinase inhibition (IC50 ...
The principal known genes for Kallmann syndrome include KAL1, which shows X-linked inheritance and codes for anosmin-1; KAL2, an autosomal-dominant form associated with mutations of fibroblast growth factor receptor 1 (FGFR1); KAL3 and KAL4, encoding prokineticin receptor-2 (PROKR2) and prok...
(H4) when located around the other Phpr molecule and chloride anions; in other words, there were two Phpr molecules and two chloride anions around the Phpr molecule in the first solvation of the shell, which was in a good agreement with the experimental results obtained by the Abbot group...
The present invention is compatible pharmaceutical cholecalciferol and 3-phenyl-5-alkoxy-1,3,4-oxadiazole-2-substituted to produce a drug which shows an inhibitory effect pancreatic lipase, PL for relates to the use of acid addition salts and salts of. In order to produce a medicament for the...
The specific influence of the neighboring electron accepting group on light absorbing molecule may have crucial importance on possible two-photon absorption properties of the dye described in this paper. Like absorption spectra, the dye also shows broad and structureless emission spectra with maximum of...
Syntheses were carried out on the assumed metabolites of bucolome (I) which comprised : (A). Compounds (XII, XIV, XVII) in which the butyl group in 5-posit... S Senda,H Izumi - 《Yakugaku Zasshi Journal of the Pharmaceutical Society of Japan》 被引量: 50发表: 1969年 Photochemical tra...
Scheme 3 shows the route taken for the synthsis of Example 5 hereinafter. Installation of the iso-propyl group at R1 of intermediate 9 from Scheme 2 was carried out in three steps. Intermediate 9 was reacted with acetic anhydride in the presence of boron trifluoride dimethylsulfide complex in...
To explain the stereochemistry of reduction observed in equation (51), (128) has been suggested, with the R-group oriented over the pinane ring in what seems at first glance an abuse of stereochemical logic. The explanation may lie in the formation of a ‘pocket’ in which the alk...