nounwhat an organism looks like as a consequence of the interaction of its genotype and the environment Related Words physical composition composition make-up makeup constitution Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc. ...
Germinate is an open source plant database infrastructure and application programming platform on which complex data from genetic resource collections can be stored, queried and visualized. mysql website vuejs database genetics climate-data phenotypes pedigree genotypes plant-genetic-resources germinate chem...
0413 Genotypes to phenotypes: Lessons from functional variation in the human genome and transcriptomedoi:10.2527/jam2016-0413Complex trait association mapping in humans has successfully identified genetic loci influencing trait variation for hundreds of different phenotypes, including disease. The vast ...
In the case of quantitative traits, a one-way analysis of variance (ANOVA) is usually performed. It tests whether the mean of a phenotype is the same in the three genotypes, AA, AB, and BB. As an alternative to ANOVA, we can perform a simple linear regression for each phenotype as a...
Metabolites are the end products of cellular regulatory processes, and their levels can be regarded as the ultimate response of biological systems to genetic or environmental changes. In parallel to the terms `transcriptome' and `proteome', the set of metabolites synthesized by a biological system ...
We hypothesize that genetic variants influence the levels and solubility of these AD-related proteins in the brain; identifying these may provide key insights into disease pathogenesis. Methods Genome-wide genotypes were collected from 441 AD cases, imputed to the haplotype reference consortium (HRC...
Finally, for some diseases, no threshold would be observed, because there would be no correlation between any genotypes and the clinical phenotypes (no-threshold model). For most “single-gene” disorders, there will be a considerable range of protein function and a significant number of alleles...
Our method amplifies highly reproducible fractions of the genome across multiple DNA samples and calls genotypes at >99% accuracy. We rapidly genotyped 14,548 SNPs in three different human populations and identified a subset of them with significant allele frequency differences between groups. We also...
Adaptation to high altitude: phenotypes and genotypes. Annu Rev Anthropol , 2014 , 43: 251 -272 CrossRef Google Scholar [3] Edea Z, Dadi H, Dessie T, et al. Genomic signatures of high-altitude adaptation in Ethiopian sheep populations. Genes Genom , 2019 , 41: 973 -981 Cross...
1b. Even chemotherapy-naive tumors undergo some broadly similar selection pressures as uncontrolled growth bounded by normal tissue (e.g., hypoxic microenvironments, mechanical-physical limitations, and altered vascularity). Under these evolutionary pressures, tumors have many genotypes that may match to...