blood pressure and heart rate. Studies in laboratory animals have shown that Phenobarbital causes reduction in the tone and contractility of theuterus, ureters, and urinarybladder. However, concentrations of the drug required to produce this effect in humans are not reached with sedative-hypnotic dos...
Effects of drugs and environmental chemicals on steroid metabolism Examples of compounds that stimulate the microsomal hydroxylation of drugs and steroids include phenobarbital, phenylbutazone, DDT, and chlordane; inhibitors of... H A.,Conney,D Ph.,... - 《Clinical Pharmacology & Therapeutics》 被...
PB had little effect on the EEG. Phenytoin at both dosages produced three main effects: (1) A negative component in the SEP which appears to be dominant in the dorsal hippocampus was significantly enhanced. (2) EEG changes occurred in the dentatothalamic pathway but not at those electrode ...
(c) a psychic dependence on the effects of the drug related to subjective and individual appreciation of those effects; and (d) a physical dependence on the effects of the drug, requiring its presence for maintenance of homeostasis and resulting in a definite, characteristic and self-limited ...
The systemic effects of exogenous and endogenous corticosteroids may be diminished by phenobarbital. Thus, this product should be administered with caution to patients with borderline hypoadrenal function, regardless of whether it is of pituitary or of primary adrenal origin. ...
Human Side Effects While phenobarbital is also a prescription medication for humans, there are different dosages and side effects for humans. If you accidentally ingest a medication intended for your pet, call your physician or the national Poison Control Center hotline at 800-222-1222. ...
Barbiturate tolerance: effects on GABA-operated chloride channel function Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for change... Andrea,M.,Allan,... - 《Brain Research》 被引量: 48发表: 1992...
Management of neonatal seizures varies widely, due in part to the lack of sufficient efficacy and safety data on available ASDs, in addition to evidence suggesting that some ASDs may have deleterious effects on brain development. In fact, no ASD has been approved by the US Food and Drug ...
2001, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone 1996, Carcinogenesis Cell proliferation and global methylation status changes in mouse liver after ph...
摘要: Comment on J Clin Invest. 2006 Jun;116(6):1703-12.关键词: Humans Osteomalacia Phenytoin Phenobarbital Carbamazepine Steroid Hydroxylases Receptors, Cytoplasmic and Nuclear Receptors, Steroid Receptors, Calcitriol Transcription Factors DOI: 10.1172/JCI30017 被引量: 8 ...