the underlying pathological mechanisms remain unclear. Emerging evidences indicate that liquid–liquid phase separation (LLPS) has great impacts on regulating human health and diseases, especially neurodegenerative diseases. A series of studies have revealed the significance...
HydrogelMechanoresponsivePhase separationMicrophase separationUnderstanding working principles and thermodynamics behind phase separations,which have significant influences on condensed molecular structures and their performances,can inspire to design and fabricate anomalously and desirably mechanoresponsive hydrogels.Howeve...
T.S. is an inventor on a patent application (WO2020027016) that describes the use of this hydrogel with GGPS. Peer review Peer review information Nature Materialsthanks Jens-Uwe Sommer and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. ...
Marine mussels achieve strong underwater adhesion by depositing mussel foot proteins (Mfps) that form coacervates during the protein secretion. However, the molecular mechanisms that govern the phase separation behaviors of the Mfps are still not fully u
Coating process and early stage adhesion evaluation of poly(2-hydroxy-ethyl-methacrylate) hydrogel coating of 316L steel surface for stent applications In this study, a spray-coating method has been set up with the aim to control the coating of poly(2-hydroxy-ethyl-methacrylate) (pHEMA), an ...
nucleic acids are concentrated ~ 10-100-fold in the dense phase [46,48], where they can reach concentrations in the millimolar range [53]; the dilute phase is maintained at the critical phase separation concentration. Experimentally, the two physical states, liquid and hydrogel, are ...
Phase separation has long been observed within aqueous mixtures of two or more different compounds, such as proteins, salts, polysaccharides and synthetic polymers. A growing body of experimental evidence indicates that phase separation also takes place
In this work, a phase change hydrogel was designed with thermally induced flexibility based on acrylamide and konjac glucomannan. The hydrogel's hydrophilic network demonstrates superior water retention properties and salt compatibility, effectively addressing the challenges of phase separation and hydrated ...
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences. Genes Dev. 33, 1619–1634 (2019). This review summarizes current strategies to characterize phase separation in vivo. Peng, S. et al. Phase separation at the nanoscale quantified by dcFCCS. Proc. Natl ...
phase separation and function of LC domains. For example, tyrosine-to-serine (Y-to-S) substitutions in a triplet sequence (G/S-Y-G/S) within the LC domain of FUS or TAF15 effectively impede phase transition into the hydrogel-like state composed of polymers21(Fig.2a). In the case of ...