An increasing number of proteins are recognized for their roles via the formation of phase separation condensates. These condensates include the nucleolus and transcription factories in the nucleus7, stress granules8, and protein densities at neuronal synapses9 and inner-ear hair cells10,11,12. ...
New in vivo functional studies have directly tested how phase separation impacts both synapse formation and function. Here, we review this emerging evidence for in vivo functional roles of phase separation at the presynapse and discuss future functional studies necessary to understand its complexity....
Phase separation at the synapse. Nat. Neurosci. 23, 301–310 (2020). Article CAS PubMed Google Scholar Diering, G. H. et al. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science 355, 511–515 (2017). Article CAS PubMed PubMed Central Google Scholar ...
C. H. (2018). Coactivator condensation at super-enhancers links phase separation and gene control....
repeats.e, αSYN phase separation in the presence of 2 mM Ca2+and crowding with 15% PEG 8000, immediately after PEG addition (t0) and after 1 h (t1h). αSYN was used at 100 µM.f, Heatmap showing turbidity measurements of αSYN phase separation in the presence of 2 mM...
Phase separation at the synapse.AFormation of presynaptic active region complex and postsynaptic dense density.B,CDomain organization and interaction network of major scaffold proteins mediating phase separation of the ePSD (B) and the active zone (C). Two-way arrows denote interactions between prote...
We review here recent studies that suggest the phase separation-mediated organization of these synaptic compartments. We discuss how synaptic function may be linked to its organization as biomolecular condensates. We conclude with a discussion of areas of future interest in the field for better ...
Separation of sister chromatids (copied chromosomes). Chromatin replicates in animal cells during ___. (a) anaphase (b) interphase (c) metaphase (d) telophase (e) prophase. In which phase of mitosis is the completion of cytokinesis? a. prophase b. metaphase c. a...
Phase separation at the synapse. Nat. Neurosci. 23, 301–310 (2020). Article CAS PubMed Google Scholar Zeng, M. et al. Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity. Cell 166, 1163–1175 (2016). Article CAS PubMed PubMed ...
Phase separation-mediated TARP/MAGUK complex condensation and AMPA receptor synaptic transmission. Neuron 104, 529–543 (2019). CAS PubMed PubMed Central Google Scholar Chen, X., Wu, X., Wu, H. & Zhang, M. Phase separation at the synapse. Nat. Neurosci. 23, 301–310 (2020). CAS ...