Evaluation in rats by combined radiochromatography and gas-liquid chromatography-mass spectrometry. Biochem. Pharmacol. 48: 1187-1197.Dionne S, Tuchweber B, Plaa GL, Yousef IM (1994) Phase I and Phase II metabolism of lithocholic acid in hepatic acinar zone 3 necrosis. Evaluation in ...
Identfication of Phase I and Phase II Metabolites of Hesperetin in Rat Liver Microsomes by Liquid Chromatography-Electrospray Ionization-Tandem Mass SpectrometryHesperetinin vitro MetabolismRat Liver MicrosomesLC/MSThe purpose of this study is to investigate the in vitro metabolism of hesperetin, a ...
Purchasing options for books and journals across Oxford Academic Short-term Access To purchase short-term access, please sign in to your personal account above. Don't already have a personal account? Register A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and ri...
M1 had a more complete set of Phase I enzymes than M2. CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A activities were present at levels similar to human hepatocytes. Phase II metabolism differed between M1 and M2. M1 conjugated hydroxycoumarin and p-nitrophenol to glucuronides only, whereas ...
3.2. Phase II Metabolism The second, and probably most important, finding was the inhibitory effect of Halowax 1051 on the activities and expression of COMT and SULT1A. The second phase of detoxification metabolism is particularly important because it leads to the formation of compounds that are ...
Significant xenobiotic metabolism is now recognized as occurring in the mammalian fetus, mostly by a range of biotransformation phase I and phase II enzymes. The fetal liver appears to be the most important organ for fetal drug metabolism[1,2]. It is well known that cytochrome (CYP)P450 is ...
Phase I metabolism is mainly oxidative reaction, including oxidation, demethylation and hydrolysis, which is catalyzed by cytochrome P450 enzyme in the liver. Phase II reaction is a binding reaction, which refers to the binding reaction of drugs or their first phase metabolites with endogenous ...
网络二期反应 网络释义 1. 二期反应 药物-1 第二期反应(Phase II metabolism) 不能发生第一類反应的药物,或经过第一類反应后的代谢产物极性仍不 够高的,可在 … ja.scribd.com|基于 1 个网页
In order to complete the knowledge of metabolic fate of CA-4, the in vitro and in vivo phase II metabolism was investigated. 2. Both in incubation with rat and human liver S9 preparation in the presence of 39-phosphoadenosine-5 -phosphosulfate (PAPS) as a cofactor the formation of a ...
the implementation of targeting metabolism in treating cancer finally underway. I am cautiously optimistic, based on the preliminary safety and efficacy results of BPM 31510 in the phase I in solid tumors, that we will be able to quickly move this agent into phase II trials in selected cancers...