Such hubris had to end in tears, of course, and phase I studies on azolastone, which commenced in 1983, revealed that the new molecular miracle provoked profound and irreversible thrombocytopenia in patients [13], particularly so on a repeat-dose schedule [14]. A companion poster from the ...
As briefly commented in the previous paragraph, the existence of these SECIS elements forming a stem-loop-stem-loop structure with near 100 nucleotides in the 3′-untranslated region of human 25 selenoprotein mRNAs is indispensable for the proper insertion of Sec in the selenoproteins. In fact, t...
Chloroquine bioavailability and elimination in man. A single dose of chloroquine was given intravenously (blue circles), as an oral solution (yellow triangles), or as tablets (purple squares). Panel A shows plasma concentration of chloroquine and panel B chloroquine metabolite. The near superposition...
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Background There is an urgent need for cheap, reproducible, easy to perform and specific biomarkers for diagnosis, differentiation and stratification of inflammatory bowel disease (IBD) patients. Te...
This happens most often within the CNS and late in the disease course. The CNS represents a distinct environment for the virus separate from the lymphoid system potentially representing a distinct reservoir in either T cells or myeloid cells. We examined the nature of rebound virus in the CSF ...
Venom composition in some snake species evolves substantially during the course of life as indicated by substantial differences in the venom components between juveniles and adults (Jackson et al., 2016; Seneci et al., 2021). Some animals co-opt venom produced by other species to their own ...
The clinical course after ingestion and inhalation typically progresses over 4 to 36 hours, and monitoring in an intensive care unit may be warranted. Patients who remain completely asymptomatic for 12 hours after oral or inhalational exposure to ricin are unlikely to develop toxicity and may be ...
The clinical course after ingestion and inhalation typically progresses over 4 to 36 hours, and monitoring in an intensive care unit may be warranted. Patients who remain completely asymptomatic for 12 hours after oral or inhalational exposure to ricin are unlikely to develop toxicity and may be ...
London & Online 21.4 Miles from Ware A seminar on biosimilars covering regulatory pathways, dossier requirements, and development strategies. Suitable for pharmaceutical professionals, the course includes insights on biological considerations... WorkshopMedical & PharmaEducation & Training Interested 1 ...