insulin.210In this way, these tumors promote cell proliferation in an autocrine manner.30,211IGF-2 also binds to the IGF-1R, whereas IGF-1 binds to its own IGF-1R and to hybrid receptors of IGF-1R and IR-A as well as IGF-1R and IR-B.30,212Physiological concentrations of insulin sho...
The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous investigations have suggested that disruption of the GSH...
Regular Articles Recent advances in pharmacology of G protein-coupled receptors Cannabinoid function in central nervous system diseases The Advanced Pharmacological Research of Chinese Herbal Medicines in Cancer and Inflammation Targeting essential metal ions in human disease: A new era of pharmacology Fighti...
Regular Articles select article Effect of statin use on cardiovascular events and all-cause mortality in immune-mediated inflammatory diseases: A systematic review and meta-analysis involving 148,722 participants Research articleAbstract only Effect of statin use on cardiovascular events and all-cause mort...
Thin layer chromatography (TLC) plates were used to monitor the reaction at regular intervals under ultraviolet irradiation. 2.1 Synthesis 2.1.1 Compound 1 Carbon disulfide (5 mmol) and 3,4-dichloroaniline (10 mmol) were added to 5 mL of water in a 50-mL round-bottom flask without ...
[81]. This break allows for restoring regular monoamine oxidase activity [81]. The case of a 57 year-old man presents the risk of combining bupropion with drugs that are mild reversible monoamine oxidase inhibitors with weak potency. As a result of a bypass graft infection, linezolid was ...
The glutathione (GSH) system is considered to be one of the most powerful endogenous antioxidant systems in the cardiovascular system due to its key contribution to detoxifying xenobiotics and scavenging overreactive oxygen species (ROS). Numerous invest
Docetaxel is the widely-used first-line therapy to treat lung cancer around the world. However, tumor progression and severe side effect occurred in some patients with docetaxel treatment. Most of the side effects were caused by immunocompromise, which l
Equine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells (MSCs), including self-renewal and multipote
In the present pharmacological space, distinctive interactions are more probable than non-distinctive interactions. Non-distinctive interactions are regular as they conform to the similarity principle. Distinguishing among the distinctive interactions requires precision. The range ofdis much higher than that ...