Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain Pain, 158 (12) (2017), pp. 2386-2395 CrossrefView in ScopusGoogle Scholar [106] R. Baron Neuropathic pain: a clinical perspective Sens. Nerves (2009), pp. 3-30 CrossrefView in ScopusGoogle Schol...
These trials provide level A evidence for the efficacy of tricyclic antidepressants, gabapentin, pregabalin and opioids, with a large number of class I trials, followed by topical lidocaine (in PHN) and the newer antidepressants venlafaxine and duloxetine (in PPN). A small number of controlled ...
Gabapentin: An update of its pharmacological properties and therapeutic use in epilepsy. The new antiepileptic medications are prescribed for the treatment of patients with seizure disorders since 17 years ago. Gabapentin (GBP) was approved on ... Honarmand,Azim,Safavi,... - 《Journal of Research...
Using a tripartite construct designed according to the results of the investigations outlined above, we were able to administer a small intramuscular injection with 1/300th of the usual oral dose of gabapentin (half life 8 hours) and achieve a degree of neuropathic pain suppression that could not...
Gabapentin 1 34 .. −0·89 (−1·42 to −0·37) Levetiracetam 1 9 .. −0·83 (−1·50 to −0·18) Pregabalin 3 199 .. −0·72 (−1·07 to −0·37) Benzodiazepines 5 112 −0·96 (−1·56 to −0·36) .. Alprazolam 1 12 .. −0·85 (−1·40...
etiesTaskForceaimedatupdatingtheexistingevidenceaboutthepharmacologicaltreatmentofneuropathicpainsince2005.Methods:StudieswereidentifiedusingtheCochraneDatabaseandMedline.Trialswereclassifiedaccordingtotheaetiologicalcondition.AllclassIandIIrandomizedcontrolledtrials(RCTs)wereassessed;lowerclassstudieswereconsideredonlyin...
Modern pharmacological pain management is based on non-opioid and opioid analgesics. NSAIDs are among the most widely prescribed class of drugs in the world. The new cyclo-oxygenase-2 inhibitors such as celecoxib and rofecoxib offer an alternative for the treatment of mild-to-moderate pain in ...
[158]. Valproic acid and benzodiazepines are also associated with cognitive impairment. Carbamazepine also is associated with many adverse effects including arrhythmia, hyponatremia, and decrease of bone marrow functions. Gabapentin is safe from the pharmacological point of view because it shows no ...
The 5-HT1receptor class comprises five different receptor subtypes, which share 41–63% overall sequence identity and couple preferentially to Gi/Goto inhibit cAMP formation (Lesch and Lerer1991). One of these, the 5-ht1Ereceptor, is given a lower-case appellation to denote that, although gene...
Future studies may consider the use of palonosetron, aprepitant and casopitant with other antiemetic agents (e.g. olanzapine, gabapentin, cannabinoids) in moderately and highly emetogenic chemotherapy, as well as in the clinical settings of multiple-day chemotherapy and bone marrow transplantation....