Use of metoprolol, ramipril, valsartan, diltiazem and atorvastatin was more at tertiary care, and atenolol, lisinopril, losartan, amlodipine and simvasatin in primary care (p<0.01).There is low use of 尾-blockers, ACE inhibitors, ARBs and statins in stable CHD patients among physicians in ...
In clinical practice, a clear understanding of potential drug interactions is essential to avoid those that could interfere with the proper course of the pharmacotherapy process, as well as to use some interactions to benefit the patients. The currently available scientific literature does not provide ...
Additionally, fluorine at para-position of benzyl moiety prevented the Biginelli adduct from metabolization by rat cells and conferred much higher potency than that of the reference drug amlodipine. Again, in vitro experiments demonstrated that the (R)-enantiomer (40a; Fig. 4) is much more ...
Calcium antagonists are potent vasodilators and are widely used in the treatment of hypertension and angina pectoris. The currently available compounds belong to three classes: (1) dihydropyridines (e.g. nifedipine, amlodipine and felodipine), (2) phenylalkylamines (e.g. verapamil) and (3) ...
of Severe VMC cohort revealed 10 hub genes which mainly clustered in GABA channel activity, extracellular matrix remodeling and sarcomere dysfunction. Using cMAP, we obtained top 10 potential medications, but only amlodipine is currently viable; (4) Conclusions: Our study finds the hub genes and ...